Major depressive disorder is a highly debilitating psychiatric disorder involving the
dysfunction of different cell types in the brain. Microglia are the predominant resident …

It has become evident that coronavirus disease 2019 (COVID-19) has a multi-organ
pathology that includes the brain and nervous system. Several studies have also reported …

Depression is a common and serious disorder, characterized by symptoms like anhedonia,
lack of energy, sad mood, low appetite, and sleep disturbances. This disease is very …

Mounting evidence shows that the complex gut microbial ecosystem in the human
gastrointestinal (GI) tract regulates the physiology of the central nervous system (CNS) via …

Dysregulated kynurenine (KYN) pathway has been implicated in the pathophysiology of
depression. In this systematic review, we examined the relationship between kynurenine …

Background Brexanolone has rapid, long-lasting, and remarkable efficacy in the treatment of
post-partum depression (PPD). We test the hypothesis that brexanolone inhibits …

Importance Maternal depression during pregnancy is associated with emotional and
behavioral difficulties of offspring during childhood that can increase the risk of depression …

Objective Disturbances in the kynurenine pathway have been implicated in the
pathophysiology of psychotic and mood disorders, as well as several other psychiatric …

Objective The mechanism of levels of inflammatory cytokines that affects brain function and
mood through gut microbiota has not been fully elucidated. This study aimed to investigate …

Low grade neuroinflammation has been suggested as one of the underlying mechanisms of
many psychiatric diseases as well as cognitive disorders. Interleukin 8 (IL-8), a …