The OncoArray Consortium: a network for understanding the genetic architecture of common cancers
Background: Common cancers develop through a multistep process often including
inherited susceptibility. Collaboration among multiple institutions, and funding from multiple …
inherited susceptibility. Collaboration among multiple institutions, and funding from multiple …
[HTML][HTML] Lung cancer is also a hereditary disease
PR Benusiglio, V Fallet, M Sanchis-Borja… - European …, 2021 - Eur Respiratory Soc
Pathogenic genetic variants (formerly called mutations) present in the germline of some
individuals are associated with a clinically relevant increased risk of developing lung cancer …
individuals are associated with a clinically relevant increased risk of developing lung cancer …
[HTML][HTML] Olaparib in patients with metastatic castration-resistant prostate cancer with DNA repair gene aberrations (TOPARP-B): a multicentre, open-label, randomised …
Background Metastatic castration-resistant prostate cancer is enriched in DNA damage
response (DDR) gene aberrations. The TOPARP-B trial aims to prospectively validate the …
response (DDR) gene aberrations. The TOPARP-B trial aims to prospectively validate the …
[HTML][HTML] Inherited DNA-repair gene mutations in men with metastatic prostate cancer
Background Inherited mutations in DNA-repair genes such as BRCA2 are associated with
increased risks of lethal prostate cancer. Although the prevalence of germline mutations in …
increased risks of lethal prostate cancer. Although the prevalence of germline mutations in …
A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer
Biallelic inactivation of BRCA1 or BRCA2 is associated with a pattern of genome-wide
mutations known as signature 3. By analyzing∼ 1,000 breast cancer samples, we confirmed …
mutations known as signature 3. By analyzing∼ 1,000 breast cancer samples, we confirmed …
Deleterious germline mutations in patients with apparently sporadic pancreatic adenocarcinoma
K Shindo, J Yu, M Suenaga… - Journal of Clinical …, 2017 - ascopubs.org
Purpose Deleterious germline mutations contribute to pancreatic cancer susceptibility and
are well documented in families in which multiple members have had pancreatic cancer …
are well documented in families in which multiple members have had pancreatic cancer …
[HTML][HTML] Genomic subtypes of non-invasive bladder cancer with distinct metabolic profile and female gender bias in KDM6A mutation frequency
Bladder cancer incurs a higher lifetime treatment cost than other cancers due to frequent
recurrence of non-invasive disease. Improved prognostic biomarkers and localized therapy …
recurrence of non-invasive disease. Improved prognostic biomarkers and localized therapy …
[HTML][HTML] BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2
The BRCA Challenge is a long-term data-sharing project initiated within the Global Alliance
for Genomics and Health (GA4GH) to aggregate BRCA1 and BRCA2 data to support highly …
for Genomics and Health (GA4GH) to aggregate BRCA1 and BRCA2 data to support highly …
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes
Genome-wide association studies have identified breast cancer risk variants in over 150
genomic regions, but the mechanisms underlying risk remain largely unknown. These …
genomic regions, but the mechanisms underlying risk remain largely unknown. These …
[HTML][HTML] BRCA1-and BRCA2-associated hereditary breast and ovarian cancer
N Petrucelli, MB Daly, T Pal - 2022 - europepmc.org
BRCA1-and BRCA2-associated hereditary breast and ovarian cancer (HBOC) is
characterized by an increased risk for female and male breast cancer, ovarian cancer …
characterized by an increased risk for female and male breast cancer, ovarian cancer …