Hypertension is available at http://hyper. ahajournals. org DOI: 10.1161/HYP.
0000000000000047 e8 Hypertension September 2016 distributed trait. Therefore, defining …

Compelling evidence for the inherited nature of essential hypertension has led to extensive
research in rats and humans. Rats have served as the primary model for research on the …

Long noncoding RNAs (lncRNAs) are an emerging class of genomic regulatory molecules
reported in various species. In the rat, which is one of the major mammalian model …

Circular RNAs (circRNAs) have emerged as an important new class of genomic regulatory
molecules contributing to the development of various diseases, but their relevance to the …

After graduating from high school, Dr Lewis Dahl moved to Seattle, Washington, to complete
his undergraduate studies at the University of Washington in 1935 (Figure 2). He then …

This study investigated the interaction between genetic differences in stress reactivity/coping
and environmental challenges, such as acute stress during adolescence on adult contextual …

Previously linkage and substitution mapping were conducted between the Dahl Salt-
sensitive (S) rat and the Spontaneously Hypertensive Rat (SHR) to address the hypothesis …

Interactions or epistasis between genetic factors may contribute to “missing heritability.”
While linkage analyses detect epistasis, defining the limits of the interacting segments poses …

Genetic analysis of polygenic traits in rats and mice has been very useful for finding the
approximate chromosomal locations of the genes causing quantitative phenotypic variation …

Abstract Purpose of Review The study aims to capture the history and lineage of
hypertension researchers from the University of Toledo in Ohio and showcase their …