The impact of transposable elements in adaptive evolution

L Schrader, J Schmitz - Molecular Ecology, 2019 - Wiley Online Library
The growing knowledge about the influence of transposable elements (TE s) on (a) long‐
term genome and transcriptome evolution;(b) genomic, transcriptomic and epigenetic …

Transposable elements as essential elements in the control of gene expression

A Gebrie - Mobile DNA, 2023 - Springer
Interspersed repetitions called transposable elements (TEs), commonly referred to as mobile
elements, make up a significant portion of the genomes of higher animals. TEs contribute in …

Pangenomic classification of pituitary neuroendocrine tumors

M Neou, C Villa, R Armignacco, A Jouinot… - Cancer cell, 2020 - cell.com
Pituitary neuroendocrine tumors (PitNETs) are common, with five main histological subtypes:
lactotroph, somatotroph, and thyrotroph (POU1F1/PIT1 lineage); corticotroph (TBX19/TPIT …

Transposable elements drive the evolution of metazoan zinc finger genes

JN Wells, NC Chang, J McCormick… - Genome …, 2023 - genome.cshlp.org
Cys2-His2 zinc finger genes (ZNFs) form the largest family of transcription factors in
metazoans. ZNF evolution is highly dynamic and characterized by the rapid expansion and …

Single-cell RNA-seq-based proteogenomics identifies glioblastoma-specific transposable elements encoding HLA-I-presented peptides

PE Bonté, YA Arribas, A Merlotti, M Carrascal… - Cell Reports, 2022 - cell.com
We analyze transposable elements (TEs) in glioblastoma (GBM) patients using a
proteogenomic pipeline that combines single-cell transcriptomics, bulk RNA sequencing …

FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells

JZ Shen, Z Qiu, Q Wu, D Finlay, G Garcia, D Sun… - Cell, 2021 - cell.com
Repetitive elements (REs) compose∼ 50% of the human genome and are normally
transcriptionally silenced, although the mechanism has remained elusive. Through an RNAi …

Role of transposable elements in genome stability: implications for health and disease

A Bhat, T Ghatage, S Bhan, GP Lahane, A Dhar… - International journal of …, 2022 - mdpi.com
Most living organisms have in their genome a sizable proportion of DNA sequences capable
of mobilization; these sequences are commonly referred to as transposons, transposable …

Unboxing the molecular modalities of mutagens in cancer

S Kumari, S Sharma, D Advani, A Khosla… - … Science and Pollution …, 2021 - Springer
The etiology of the majority of human cancers is associated with a myriad of environmental
causes, including physical, chemical, and biological factors. DNA damage induced by such …

Piwi-interacting RNAs (piRNAs) and cancer: Emerging biological concepts and potential clinical implications

W Weng, H Li, A Goel - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2019 - Elsevier
Piwi-interacting RNAs (piRNAs) are a very recently discovered class of small non-coding
RNAs (ncRNAs), with approximately 20,000 piRNA genes already identified within the …

Cell‐free DNA as a biomarker of aging

YV Teo, M Capri, C Morsiani, G Pizza, AMC Faria… - Aging cell, 2019 - Wiley Online Library
Cell‐free DNA (cfDNA) is present in the circulating plasma and other body fluids and is
known to originate mainly from apoptotic cells. Here, we provide the first in vivo evidence of …