Epigenomic signatures reveal mechanistic clues and predictive markers for autism spectrum disorder
JM LaSalle - Molecular psychiatry, 2023 - nature.com
Autism spectrum disorder (ASD) comprises a heterogeneous group of neurodevelopmental
outcomes in children with a commonality in deficits in social communication and language …
outcomes in children with a commonality in deficits in social communication and language …
Rethinking intellectual disability from neuro-to astro-pathology
Á Fernández-Blanco, M Dierssen - International Journal of Molecular …, 2020 - mdpi.com
Neurodevelopmental disorders arise from genetic and/or from environmental factors and are
characterized by different degrees of intellectual disability. The mechanisms that govern …
characterized by different degrees of intellectual disability. The mechanisms that govern …
The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis
IS Muskens, S Li, T Jackson, N Elliot… - Nature …, 2021 - nature.com
Down syndrome is associated with genome-wide perturbation of gene expression, which
may be mediated by epigenetic changes. We perform an epigenome-wide association study …
may be mediated by epigenetic changes. We perform an epigenome-wide association study …
Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes
Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder with
complex heritability and higher prevalence in males. The neonatal epigenome has the …
complex heritability and higher prevalence in males. The neonatal epigenome has the …
Low-pass whole genome bisulfite sequencing of neonatal dried blood spots identifies a role for RUNX1 in Down syndrome DNA methylation profiles
Neonatal dried blood spots (NDBS) are a widely banked sample source that enables
retrospective investigation into early life molecular events. Here, we performed low-pass …
retrospective investigation into early life molecular events. Here, we performed low-pass …
[HTML][HTML] Long-term effects of wildfire smoke exposure during early life on the nasal epigenome in rhesus macaques
Background Wildfire smoke is responsible for around 20% of all particulate emissions in the
US and affects millions of people worldwide. Children are especially vulnerable, as ambient …
US and affects millions of people worldwide. Children are especially vulnerable, as ambient …
Pterostilbene leads to DNMT3B-mediated DNA methylation and silencing of OCT1-targeted oncogenes in breast cancer cells
M Beetch, C Boycott, S Harandi-Zadeh, T Yang… - The Journal of nutritional …, 2021 - Elsevier
Transcription factor (TF)-mediated regulation of genes is often disrupted during
carcinogenesis. The DNA methylation state of TF-binding sites may dictate transcriptional …
carcinogenesis. The DNA methylation state of TF-binding sites may dictate transcriptional …
DNMT3L promotes neural differentiation by enhancing STAT1 and STAT3 phosphorylation independent of DNA methylation
Previously, we reported global hypermethylation in DS might be attributed to the
overexpression of HSA21 gene DNMT3L, which can enhance DNMT3A and DNMT3B …
overexpression of HSA21 gene DNMT3L, which can enhance DNMT3A and DNMT3B …
DNA methylation changes in Down syndrome derived neural iPSCs uncover co-dysregulation of ZNF and HOX3 families of transcription factors
Background Down syndrome (DS) is characterized by neurodevelopmental abnormalities
caused by partial or complete trisomy of human chromosome 21 (T21). Analysis of Down …
caused by partial or complete trisomy of human chromosome 21 (T21). Analysis of Down …
Stable DNMT3L overexpression in SH-SY5Y neurons recreates a facet of the genome-wide Down syndrome DNA methylation signature
Background Down syndrome (DS) is characterized by a genome-wide profile of differential
DNA methylation that is skewed towards hypermethylation in most tissues, including brain …
DNA methylation that is skewed towards hypermethylation in most tissues, including brain …