Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

Animal development requires a carefully orchestrated cascade of cell fate specification
events and cellular movements. A surprisingly small number of choreographed cellular …

During cancer progression, malignant cells undergo epithelial-mesenchymal transitions
(EMT) and mesenchymal-epithelial transitions (MET) as part of a broad invasion and …

Abstract miRNAs are master regulators of gene expression that play key roles in cancer
metastasis. During bone metastasis, metastatic tumor cells must rewire their biology and …

Prostate cancer is a complex disease in which metastasis to the bone is the main cause of
death. Initial stages of metastasis are generally similar to those for most solid tumors; …

Epithelial to mesenchymal transition (EMT) is an oft-studied mechanism for the initiation of
metastasis. We have recently shown that once cancer cells disseminate to a secondary …

The COL11A1 human gene codes for the α1 chain of procollagen 11A1 and mature
collagen 11A1, an extracellular minor fibrillar collagen. Under regular conditions, this gene …

An important clinical challenge in prostate cancer therapy is the inevitable transition from
androgen-sensitive to castration-resistant and metastatic prostate cancer. Albeit the …

About one-third of patients with advanced renal cell carcinoma (RCC) have bone metastasis
that are often osteolytic and cause substantial morbidity, such as pain, pathologic fracture …

Bone metastases are dejected consequences of many types of tumors including breast,
prostate, lung, kidney, and thyroid cancers. This complicated process begins with the …