Alzheimer's disease (AD) is the most common type of dementia and is characterized by the
accumulation of amyloid (Aβ) plaques and neurofibrillary tangles in the brain. Much attention …

Alzheimer's disease (AD) is a neurodegenerative disease with a high incidence rate. The
main pathological features of AD are β-amyloid plaques (APs), which are formed by β …

Goat domestication was critical for agriculture and civilization, but its underlying genetic
changes and selection regimes remain unclear. Here, we analyze the genomes of …

The Aceramic Neolithic (∼ 9600 to 7000 cal BC) period in the Zagros Mountains, western
Iran, provides some of the earliest archaeological evidence of goat (Capra hircus) …

Abstract Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder
often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta …

Store-operated calcium entry (SOCE) is the flow of calcium ions (Ca 2+) into cells in
response to the depletion of intracellular Ca 2+ stores that reside predominantly in the …

Stromal interaction molecules (STIMs), including STIM1 and STIM2, are single-pass
transmembrane proteins that are located predominantly in the endoplasmic reticulum (ER) …

Huntington's disease (HD) is a progressive neurodegenerative disorder that is characterized
by motor, cognitive, and psychiatric problems. It is caused by a polyglutamine expansion in …

Store operated Ca2+ entry (SOCE) is a ubiquitous signalling module with established roles
in the immune system, secretion and muscle development. Recent evidence supports a …

STIM1 is an endoplasmic reticulum protein with a role in Ca 2+ mobilization and signaling.
As a sensor of intraluminal Ca 2+ levels, STIM1 modulates plasma membrane Ca 2+ …