Psoriasis is a chronic inflammatory skin disease characterized by scaly indurated erythema.
This disease impairs patients' quality of life enormously. Pathological findings demonstrate …

Background: Psoriasis is a common, chronic inflammatory skin disorder, which can
significantly impact quality of life. Despite major breakthroughs in our understanding of the …

Macroautophagy/autophagy is a cellular catabolic process that is implicated in several
physiological and pathological processes. However, the role of epidermal autophagy in …

The attraction of leukocytes to tissues is essential for inflammation and the host response to
infection. The process is controlled by chemokines, which are chemotactic cytokines. This …

Healing of wounds is one of the most complex biological events afterbirth as a result of the
interplay of different tissue structures and alarge number of resident and infiltrating cell …

Background Biologic therapies such as adalimumab, a tumour necrosis factor antagonist,
are safe and effective in the treatment of moderate to severe chronic plaque psoriasis …

GAO, Jintao et al. Daphnetin inhibits proliferation and inflammatory response in human
HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice …

CC chemokine receptor 2 (CCR2) is a prominent receptor for the monocyte chemoattractant
protein (MCP) group of CC chemokines. Mice generated by gene targeting to lack CCR2 …

Autoimmunity plays a key role in the immunopathogenesis of psoriasis; however, little is
known about the recruitment of pathogenic cells to skin lesions. We report here that the CC …

Healing of cutaneous wounds requires a complex integrated network of repair mechanisms,
including the action of newly recruited leukocytes. Using a skin repair model in adult …