Highlights•Modulation of synaptic strength can occur through changes in short-term
plasticity.•Modulators can shape or induce long-term synaptic plasticity.•Modulators can …

Dopamine (DA) midbrain neurons project to several striatal and cortical target areas and are
essentially involved in a puzzling variety of important brain functions such as action …

Midbrain dopaminergic neurons are essential for appropriate voluntary movement, as
epitomized by the cardinal motor impairments arising in Parkinson's disease. Understanding …

Catecholamines modulate the impact of motivational cues on action. Such motivational
biases have been proposed to reflect cue-based,'Pavlovian'effects. Here, we assess …

The dorsal (DS) and ventral striatum (VS) receive dopaminergic projections that control
motor functions and reward-related behavior. It remains poorly understood how dopamine …

Decades of research suggest that the mesocortical dopamine system exerts powerful control
over mPFC physiology and function. Indeed, dopamine signaling in the medial prefrontal …

Movement disorders arise from the complex interplay of multiple changes to neural circuits.
Successful treatments for these disorders could interact with these complex changes in …

Tonic neurochemical dopamine activity underlies many brain functions; however a
consensus on this important concentration has not yet been reached. In this work, we …

Egalitarian motives form a powerful force in promoting prosocial behavior and enabling
large-scale cooperation in the human species [1]. At the neural level, there is substantial …

Computational modeling of dopamine transmission is challenged by complex underlying
mechanisms. Here we present a new computational model that (I) simultaneously regards …