The growth and migration of neurons require continuous remodelling of the neuronal
cytoskeleton, providing a versatile cellular framework for force generation and guided …

Neurodegenerative disorders like Parkinson's disease, Alzheimer's disease, or amyotrophic
lateral sclerosis are affecting a rapidly increasing population worldwide. While common …

In the axons of cultured hippocampal neurons, actin forms various structures, including
bundles, patches (involved in the preservation of neuronal polarity), and a recently reported …

Although the presynaptic protein α-synuclein is a recognized player in neurodegeneration,
its precise physiologic function (s) and/or role in human disease remains unclear. An …

The axon is the single long fiber that extends from the neuron and transmits electrical
signals away from the cell body. The neuronal cytoskeleton, composed of microtubules …

Bassoon and Piccolo are two very large scaffolding proteins of the cytomatrix assembled at
the active zone (CAZ) where neurotransmitter is released. They share regions of high …

Although actin at neuronal growth cones is well-studied, much less is known about actin
organization and dynamics along axon shafts and presynaptic boutons. Using probes that …

The presynaptic active zone (AZ) is a specialized microdomain designed for the efficient and
repetitive release of neurotransmitter. Bassoon and Piccolo are two high molecular weight …

The regulated release of neurotransmitter occurs via the fusion of synaptic vesicles (SV s) at
specialized regions of the presynaptic membrane called active zones (AZ s). These regions …

F-actin bundling plastin 3 (PLS3) is a fully protective modifier of the neuromuscular disease
spinal muscular atrophy (SMA), the most common genetic cause of infant death. The …