Extracellular matrix (ECM) macromolecules together with a multitude of different molecules
residing in the extracellular space play a vital role in the regulation of cellular phenotype and …

Cell traction force plays a critical role in directing cellular functions, such as proliferation,
migration, and differentiation. Current understanding of cell traction force is largely derived …

It is well established that the early malignant tumor invades surrounding extracellular matrix
(ECM) in a manner that depends upon material properties of constituent cells, surrounding …

Tumor invasion within the interstitial space is critically regulated by the force balance
between cell-extracellular matrix (ECM) and cell-cell interactions. Interstitial flows (IFs) are …

Mechanical properties of the extracellular matrix (ECM) critically regulate a number of
important cell functions including growth, differentiation and migration. Type I collagen and …

Damage accumulation in long-living macromolecules (especially extracellular matrix (ECM)
proteins, nuclear pore complex (NPC) proteins, and histones) is a missing hallmark of aging …

The receptor for advanced glycation end-products (RAGE) is a multiligand binding and
single-pass transmembrane protein which actively participates in several chronic …

Biophysical properties of extracellular matrix (ECM), such as matrix stiffness, viscoelasticity
and matrix fibrous structure, are emerging as important factors that regulate progression of …

Invading cancer cells adapt their migration phenotype in response to mechanical and
biochemical cues from the extracellular matrix. For instance, mesenchymal migration is …

Glioblastoma (GBM) is a highly aggressive and invasive brain tumor with a poor prognosis
despite extensive treatment. The switch to aerobic glycolysis, known as the Warburg effect …