The formation of nitric oxide in biological systems has led to the discovery of a number of
post-translational protein modifications that could regulate protein function or potentially be …

Adaptive responses associated with environmental stressors are critical to cell survival.
Under conditions when cellular redox and antioxidant defenses are overwhelmed, the …

There is growing evidence that oxidative phosphorylation (OXPHOS) generates reactive
oxygen and nitrogen species within mitochondria as unwanted byproducts that can damage …

Increased abundance of nitrotyrosine modifications of proteins have been documented in
multiple pathologies in a variety of tissue types and play a role in the redox regulation of …

In the aging heart, decreased rates of calcium transport mediated by the SERCA2a isoform
of the sarcoplasmic reticulum (SR) Ca-ATPase are responsible for the slower sequestration …

Abstract Calcium (Ca 2+) is an ubiquitous key second messenger in plants, where it
modulates many developmental and adaptive processes in response to various stimuli …

Reactive‐nitrogen species (RNS) such as peroxynitrite (ONOO−), that is, the reaction
product of nitric oxide (• NO) and superoxide (O2−•), nitryl chloride (NO2Cl) and• NO2 react …

Background: The post-translational modification of tyrosine nitration is an important
covalently substituted process in many biochemical processes that are closely related to …

Posttranslational modifications (PTMs) are covalent modifications of proteins that modulate
the structure and functions of proteins and regulate biological processes. The development …

Elevated levels of protein tyrosine nitration have been found in various neurodegenerative
diseases and age-related pathologies. Until recently, however, the lack of an efficient …