Poly-adenosine diphosphate-ribose polymerases (PARPs) promote ADP-ribosylation, a
highly conserved, fundamental posttranslational modification (PTM). PARP catalytic …

The protein family of poly (ADP-ribose) polymerases (PARPs) or diphtheria toxin-type ADP-
ribose transferases (ARTDs) are multidomain proteins originally identified as DNA repair …

PARP14 is a mono–ADP-ribosyl transferase involved in the control of immunity,
transcription, and DNA replication stress management. However, little is known about the …

The poly (adenosine diphosphate (ADP)-ribose) polymerase (PARP) protein family
generates ADP-ribose (ADPr) modifications onto target proteins using NAD+ as substrate …

Posttranslational modifications (PTMs) regulate protein functions and interactions. ADP-
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …

Despite the global impact of macrophage activation in vascular disease, the underlying
mechanisms remain obscure. Here we show, with global proteomic analysis of macrophage …

Resistance mechanisms to immune checkpoint blockade therapy (ICBT) limit its response
duration and magnitude. Paradoxically, Interferon γ (IFNγ), a key cytokine for cellular …

Most tumour cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and
evade apoptosis. Intriguingly, the molecular mechanisms that link the Warburg effect with the …

Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous lymphoid malignancy
and the most common subtype of non-Hodgkin's lymphoma in adults, with one of the highest …

The members of the Poly (ADP‐ribose) polymerase (PARP) superfamily are involved in
several biological processes and, in particular, in the DNA damage response (DDR). The …