Cardiac fibrosis is a common pathophysiological remodeling process that occurs in a variety
of cardiovascular diseases and greatly influences heart structure and function, progressively …

The goal of this study was to develop an atlas of the metabolic, transcriptional, and
proteomic changes that occur with pregnancy in the maternal heart. Timed pregnancy …

Although the structural and functional effects of exercise on the heart are well established,
the metabolic changes that occur in the heart during and after exercise remain unclear. In …

Background Members of the cellular communication network family (CCN) of matricellular
proteins, like CCN1, have long been implicated in the regulation of cellular processes …

The cardiac extracellular matrix plays essential roles in homeostasis and injury responses.
Although the role of fibrillar collagens have been thoroughly documented, the functions of …

Inhibitors of sodium glucose cotransporter-2 (SGLT2i) demonstrate strong symptomatic and
mortality benefits in the treatment of heart failure but appear to do so independently of …

Background The extracellular matrix (ECM) provides structural and functional support for the
myocardium, but myocardial infarction (MI) changes the composition of the ECM. One of the …

Cardiac substrate utilization remains a critical focus for the research community. 1 Research
has acknowledged the role of metabolic flexibility in the development and progression of …

Introduction Polychlorinated biphenyls (PCBs) are persistent environmental toxicants that
have been implicated in numerous health disorders including liver diseases such as non …

Objective To investigate pantothenate kinases 1 (PANK1) expression in kidney renal clear
cell carcinoma (KIRC) tissues, analyze its correlation with clinicopathological features and …