EFG1, Everyone's Favorite Gene in Candida albicans: A Comprehensive Literature Review

VE Glazier - Frontiers in Cellular and Infection Microbiology, 2022 - frontiersin.org
Candida sp. are among the most common fungal commensals found in the human
microbiome. Although Candida can be found residing harmlessly on the surface of the skin …

Bibliometric analysis and thematic review of Candida pathogenesis: Fundamental omics to applications as potential antifungal drugs and vaccines

SJ Lim, ND Muhd Noor, S Sabri… - Medical …, 2024 - academic.oup.com
Invasive candidiasis caused by the pathogenic Candida yeast species has resulted in
elevating global mortality. The pathogenicity of Candida spp. is not only originated from its …

Reinforcement amid genetic diversity in the Candida albicans biofilm regulatory network

MV Cravener, E Do, G May, R Zarnowski… - PLoS …, 2023 - journals.plos.org
Biofilms of the fungal pathogen Candida albicans include abundant long filaments called
hyphae. These cells express hypha-associated genes, which specify diverse virulence …

Intravital imaging-based genetic screen reveals the transcriptional network governing Candida albicans filamentation during mammalian infection

RS Wakade, LC Ristow, M Wellington, DJ Krysan - Elife, 2023 - elifesciences.org
Candida albicans is one of the most common human fungal pathogens. C. albicans
pathogenesis is tightly linked to its ability to under a morphogenetic transition from typically …

Candida albicans oscillating UME6 expression during intestinal colonization primes systemic Th17 protective immunity

TY Shao, P Kakade, JN Witchley, C Frazer, KL Murray… - Cell reports, 2022 - cell.com
Systemic immunity is stringently regulated by commensal intestinal microbes, including the
pathobiont Candida albicans. This fungus utilizes various transcriptional and morphological …

Proline catabolism is a key factor facilitating Candida albicans pathogenicity

FGS Silao, T Jiang, B Bereczky-Veress… - PLoS …, 2023 - journals.plos.org
Candida albicans, the primary etiology of human mycoses, is well-adapted to catabolize
proline to obtain energy to initiate morphological switching (yeast to hyphal) and for growth …

Transcriptomics analysis reveals the effect of Pulsatilla decoction butanol extract on endoplasmic reticulum and peroxisome function of Candida albicans in hyphal …

F Chu, H Wu, C Li, W Qiu, L Zang, D Wu, J Shao… - Journal of …, 2025 - Elsevier
Abstract Ethnopharmacological relevance The traditional Chinese medicine formula known
as Pulsatilla decoction was utilized to treat conditions such as bacterial dysentery, ulcerative …

Systematic analysis of the Candida albicans kinome reveals environmentally contingent protein kinase-mediated regulation of filamentation and biofilm formation in …

J Kramara, MJ Kim, TL Ollinger, LC Ristow… - Mbio, 2024 - journals.asm.org
Protein kinases are critical regulatory proteins in both prokaryotes and eukaryotes.
Accordingly, protein kinases represent a common drug target for a wide range of human …

Systematic genetic interaction analysis identifies a transcription factor circuit required for oropharyngeal candidiasis

NV Solis, RS Wakade, VE Glazier, TL Ollinger… - MBio, 2022 - Am Soc Microbiol
Oropharyngeal candidiasis (OPC) is a common infection that complicates a wide range of
medical conditions and can cause either mild or severe disease depending on the patient …

Evaluation of Anti-Candida Potential of Piper nigrum Extract in Inhibiting Growth, Yeast-Hyphal Transition, Virulent Enzymes, and Biofilm Formation

CP Bravo-Chaucanés, Y Vargas-Casanova… - Journal of Fungi, 2022 - mdpi.com
Due to the increased incidence of fungal infections and the emergence of antifungal
resistance mainly by Candida species, the need for safe and effective novel therapies is …