The immunosuppressive activity of artemisinin‐type drugs towards inflammatory and autoimmune diseases

T Efferth, F Oesch - Medicinal research reviews, 2021 - Wiley Online Library
The sesquiterpene lactone artemisinin from Artemisia annua L. is well established for
malaria therapy, but its bioactivity spectrum is much broader. In this review, we give a …

[HTML][HTML] Progress in the Application of Drugs for the Treatment of Multiple Sclerosis

W Wei, D Ma, L Li, L Zhang - Frontiers in Pharmacology, 2021 - frontiersin.org
Multiple sclerosis (MS) is an autoimmune and chronic inflammatory demyelinating disease
of the central nervous system (CNS), which gives rise to focal lesion in CNS and cause …

Artemisinins: Promising drug candidates for the treatment of autoimmune diseases

X Gao, X Lin, Q Wang, J Chen - Medicinal Research Reviews, 2024 - Wiley Online Library
Autoimmune diseases are characterized by the immune system's attack on one's own
tissues which are highly diverse and diseases differ in severity, causing damage in virtually …

[HTML][HTML] miR-23b suppresses leukocyte migration and pathogenesis of experimental autoimmune encephalomyelitis by targeting CCL7

Y Zhang, JJ Han, XY Liang, L Zhao, F Zhang… - Molecular Therapy, 2018 - cell.com
MicroRNAs (miRNAs) are small, non-coding RNAs involved in immune response regulation.
Specific miRNAs have been linked to the development of various autoimmune diseases; …

[HTML][HTML] Immunoregulation by artemisinin and its derivatives: a new role for old antimalarial drugs

F Qiu, J Liu, X Mo, H Liu, Y Chen, Z Dai - Frontiers in Immunology, 2021 - frontiersin.org
Artemisinin and its derivatives (ARTs) are known as conventional antimalarial drugs with
clinical safety and efficacy. Youyou Tu was awarded a Nobel Prize in Physiology and …

Artemisinin derivative SM934 in the treatment of autoimmune and inflammatory diseases: therapeutic effects and molecular mechanisms

X Tong, L Chen, S He, J Zuo - Acta Pharmacologica Sinica, 2022 - nature.com
Artemisinin and its derivatives are the well-known anti-malarial drugs derived from a
traditional Chinese medicine. In addition to antimalarial, artemisinin and its derivatives …

[HTML][HTML] Carnosol modulates Th17 cell differentiation and microglial switch in experimental autoimmune encephalomyelitis

X Li, L Zhao, JJ Han, F Zhang, S Liu, L Zhu… - Frontiers in …, 2018 - frontiersin.org
Medicinal plants as a rich pool for developing novel small molecule therapeutic medicine
have been used for thousands of years. Carnosol as a bioactive diterpene compound …

Artesunate prevents type 1 diabetes in NOD mice mainly by inducing protective IL‐4—producing T cells and regulatory T cells

Z Li, X Shi, J Liu, F Shao, G Huang, Z Zhou… - The FASEB …, 2019 - Wiley Online Library
ABSTRACT Type 1 diabetes (T1D) is an autoimmune disease characterized by the immune‐
mediated destruction of insulin‐producing β cells. Recent studies showed that in addition to …

[HTML][HTML] Chemical Composition and Immunomodulatory Activity of Essential Oils from Rhododendron albiflorum

IA Schepetkin, G Özek, T Özek, LN Kirpotina… - Molecules, 2021 - mdpi.com
Rhododendron (Ericaceae) extracts contain flavonoids, chromones, terpenoids, steroids,
and essential oils and are used in traditional ethnobotanical medicine. However, little is …

TPN10466 ameliorates Concanavalin A‐induced autoimmune hepatitis in mice via inhibiting ERK/JNK/p38 signaling pathway

G Liu, Y Zhang, S Han, W Zhuang, J Lv… - European Journal of …, 2023 - Wiley Online Library
Autoimmune hepatitis (AIH) eventually progresses to liver fibrosis, cirrhosis, and even
hepatocellular carcinoma, causing irreversible damage to the liver. Concanavalin A …