Notch signaling pathway: architecture, disease, and therapeutics
B Zhou, W Lin, Y Long, Y Yang, H Zhang… - Signal transduction and …, 2022 - nature.com
The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …
Vertebrate neural cell-fate determination: lessons from the retina
FJ Livesey, CL Cepko - Nature Reviews Neuroscience, 2001 - nature.com
Postmitotic neurons are produced from a pool of cycling progenitors in an orderly fashion
during development. Studies of cell-fate determination in the vertebrate retina have …
during development. Studies of cell-fate determination in the vertebrate retina have …
TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
LW Ellisen, J Bird, DC West, AL Soreng, TC Reynolds… - Cell, 1991 - cell.com
Previously we described joining of DNA in the 9 T cell receptor gene to DNA of an
uncharacterized locus in at (7; 9)(q34; q34. 3) chromosomal translocation from a case of …
uncharacterized locus in at (7; 9)(q34; q34. 3) chromosomal translocation from a case of …
Notch signaling
S Artavanis-Tsakonas, K Matsuno, ME Fortini - Science, 1995 - science.org
The Notch/Lin-12/Glp-1 receptor family mediates the specification of numerous cell fates
during development in Drosophila and Caenorhabditis elegans. Studies on the expression …
during development in Drosophila and Caenorhabditis elegans. Studies on the expression …
Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor
I Rebay, RJ Fleming, RG Fehon, L Cherbas, P Cherbas… - Cell, 1991 - cell.com
The neurogenic loci Notch and Delta, which both encode EGF-homologous transmembrane
proteins, appear to function together in mediating cell-cell communication and have been …
proteins, appear to function together in mediating cell-cell communication and have been …
Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation
CM Smas, HS Sul - Cell, 1993 - cell.com
With the aim of identifying novel regulators of adipocyte differentiation, we have cloned and
characterized preadfpocyte factor 1 (pref-1), a novel member of the epidermal growth factor …
characterized preadfpocyte factor 1 (pref-1), a novel member of the epidermal growth factor …
Notch1 is essential for postimplantation development in mice.
PJ Swiatek, CE Lindsell, FF Del Amo… - Genes & …, 1994 - genesdev.cshlp.org
The Notch gene of Drosophila encodes a large transmembrane protein involved in cell fate
determination during embryonic and larval development. This gene is evolutionarily …
determination during embryonic and larval development. This gene is evolutionarily …
Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
CM Blaumueller, H Qi, P Zagouras… - Cell, 1997 - cell.com
Previous models for signal transduction via the Notch pathway have depicted the full-length
Notch receptor expressed at the cell surface. We present evidence demonstrating that the …
Notch receptor expressed at the cell surface. We present evidence demonstrating that the …
Notch1 is required for the coordinate segmentation of somites
Members of the Notch family of transmembrane receptors mediate a number of
developmental decisions in invertebrates. In order to study Notch function in a vertebrate …
developmental decisions in invertebrates. In order to study Notch function in a vertebrate …
Identification of neurogenin, a vertebrate neuronal determination gene
Q Ma, C Kintner, DJ Anderson - Cell, 1996 - cell.com
Several bHLH proteins are involved in vertebrate neurogenesis, but those controlling early
stages of neuronal determination have not yet been identified. Here we describe a novel …
stages of neuronal determination have not yet been identified. Here we describe a novel …