The non-structural (NS1) protein of influenza A viruses is a non-essential virulence factor
that has multiple accessory functions during viral infection. In recent years, the major role …

The development of reverse genetics techniques allowing the rescue of influenza virus from
plasmid DNA has opened up the possibility of inserting mutations into the genome of this …

Influenza A virus (IAV) has shown promise as an oncolytic agent. To improve IAV as an
oncolytic virus, we sought to design a transgenic virus expressing an immune checkpoint …

The avian influenza A virus currently prevailing in Asia causes fatal pneumonia and multiple
organ failure in birds and humans. Despite intensive research, understanding of the …

Purpose: To determine whether the synthetic microRNAs (miRNA) could effectively target
tumor cells we designed several miRNA complementary to glioma-associated antigen-1 (Gli …

Oncolytic viruses constitute an emerging strategy in immunomodulatory cancer treatment.
The first oncolytic virus, Talimogene laherparepvec (T-VEC), based on herpes simplex virus …

Based on personal acquaintances and experience dating back to the early 1950s, the senior
author reviews the history of viral therapy of cancer. He points out the difficulties …

Influenza virus is a common virus in people's daily lives, and it has certain infectivity in
humans and animals. Influenza viruses have the characteristics of a high mutation rate and …

Cancer stem cells (CSC) are resistant to chemo-and radiotherapy. To eliminate cells with
phenotypic markers of CSC-like we characterized:(1) expression of CD44, CD24, CD133 …

As the most common cancer of the genitourinary system, prostate cancer (PCa) is a global
men′ s health problem whose treatments are an urgent research issue. Treatment options …