Cerebral ischemia-reperfusion is a complicated pathological process. The injury and
cascade reactions caused by cerebral ischemia and reperfusion are characterized by high …

Human neurons are functional over an entire lifetime, yet the mechanisms that preserve
function and protect against neurodegeneration during ageing are unknown. Here we show …

During neurogenesis, specific transcription factors are needed to repress neuronal genes in
nonneuronal cells to ensure precise development. Repressor element-1 binding …

Parkinson's disease (PD) and Alzheimer's disease (AD) are the most common
neurodegenerative diseases and have been suggested to share common pathological and …

Chromatin modifications play a crucial role in the regulation of gene expression. The
repressor element-1 (RE1) silencing transcription factor (REST), also known as neuron …

REST [RE1-silencing transcription factor (also called neuron-restrictive silencer factor)] is
known to repress thousands of possible target genes, many of which are neuron specific. To …

Abstract Background/Aims: It is known that the activation of hepatic stellate cells (HSCs) is a
pivotal step in the initiation and progression of liver fibrosis. Aberrant activated Wnt/β-catenin …

Although transplantation of human mesenchymal stem cells (MSCs) derived from amnion
(hAMSCs), bone marrow (hBMSCs) and adipose tissues (hADSCs) has been shown to aid …

Neuron-restrictive silencer factor (NRSF) blocks the expression of many neuronal genes in
non-neuronal cells and neural stem cells. There is growing body of evidence that NRSF …

The neuron-restrictive silencer factor (NRSF), also known as repressor element 1 (RE-1)
silencing transcription factor (REST) or X2 box repressor (XBR), is a zinc finger transcription …