Cyclic guanosine monophosphate (cGMP) is a unique second messenger molecule formed
in different cell types and tissues. cGMP targets a variety of downstream effector molecules …

Sickle cell disease is an inherited disorder of hemoglobin (Hb) synthesis, caused by a single
nucleotide substitution (GTG> GAG) at the sixth codon of the β-globin gene, leading to the …

The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant
pathophysiological consequences that result in hemolytic events and the induction of the …

Nitric oxide (NO)-sensitive soluble guanylyl cyclase (sGC), an enzyme that catalyzes the
conversion of guanosine-5′-triphosphate (GTP) to cyclic guanosine-3′, 5 …

Inhibition of leukocyte adhesion to the vascular endothelium represents a novel and
important approach for decreasing sickle cell disease (SCD) vaso-occlusion. Using a …

Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by chronic
anemia, intravascular hemolysis, and the occurrence of vaso-occlusive crises due to the …

Sickle cell disease (SCD) is a complex, clinically heterogeneous disorder affecting
approximately 100,000 individuals in the United States and millions worldwide. The disease …

Simple Summary Beta-thalassemia (β-thalassemia) is an autosomal recessive inherited
disorder that causes decreased production of hemoglobin. Ineffective erythropoiesis and …

After years of reliance on transfusion alone to address anemia and suppress ineffective
erythropoiesis in β-thalassemia, many new therapies are now in development. Luspatercept …

Background Divalent metal transporter 1 (DMT1) is a widely expressed metal-iron
transporter gene encoding four variant mRNA transcripts, differing for alternative promoter at …