Direct trafficking pathways from the Golgi apparatus to the plasma membrane

D Stalder, DC Gershlick - Seminars in cell & developmental biology, 2020 - Elsevier
In eukaryotic cells, protein sorting is a highly regulated mechanism important for many
physiological events. After synthesis in the endoplasmic reticulum and trafficking to the Golgi …

Determinants of glycosaminoglycan (GAG) structure

K Prydz - Biomolecules, 2015 - mdpi.com
Proteoglycans (PGs) are glycosylated proteins of biological importance at cell surfaces, in
the extracellular matrix, and in the circulation. PGs are produced and modified by …

Multiple roles for actin in secretory and endocytic pathways

R Chakrabarti, M Lee, HN Higgs - Current Biology, 2021 - cell.com
Actin filaments play multiple roles in the secretory pathway and in endosome dynamics in
mammals, including maintenance of Golgi structure, release of membrane cargo from the …

Nutrient regulation of pancreatic islet β-cell secretory capacity and insulin production

KE Rohli, CK Boyer, SE Blom, SB Stephens - Biomolecules, 2022 - mdpi.com
Pancreatic islet β-cells exhibit tremendous plasticity for secretory adaptations that coordinate
insulin production and release with nutritional demands. This essential feature of the β-cell …

How viruses hijack and modify the secretory transport pathway

Z Hassan, ND Kumar, F Reggiori, G Khan - Cells, 2021 - mdpi.com
Eukaryotic cells contain dynamic membrane-bound organelles that are constantly
remodeled in response to physiological and environmental cues. Key organelles are the …

Activity of the SPCA1 calcium pump couples sphingomyelin synthesis to sorting of secretory proteins in the trans-Golgi network

Y Deng, M Pakdel, B Blank, EL Sundberg, CG Burd… - Developmental cell, 2018 - cell.com
How the principal functions of the Golgi apparatus—protein processing, lipid synthesis, and
sorting of macromolecules—are integrated to constitute cargo-specific trafficking pathways …

Cryo-EM structures of human SPCA1a reveal the mechanism of Ca2+/Mn2+ transport into the Golgi apparatus

Z Chen, S Watanabe, H Hashida, M Inoue… - Science …, 2023 - science.org
Secretory pathway Ca2+/Mn2+ ATPase 1 (SPCA1) actively transports cytosolic Ca2+ and
Mn2+ into the Golgi lumen, playing a crucial role in cellular calcium and manganese …

Sending out molecules from the TGN

BR Ramazanov, ML Tran, J von Blume - Current opinion in cell biology, 2021 - Elsevier
The sorting of secreted cargo proteins and their export from the trans-Golgi network (TGN)
remains an enigma in the field of membrane trafficking; although the sorting mechanisms of …

Primary active Ca2+ transport systems in health and disease

J Chen, A Sitsel, V Benoy… - Cold Spring …, 2020 - cshperspectives.cshlp.org
Calcium ions (Ca2+) are prominent cell signaling effectors that regulate a wide variety of
cellular processes. Among the different players in Ca2+ homeostasis, primary active Ca2+ …

Lipid‐dependent coupling of secretory cargo sorting and trafficking at the trans‐Golgi network

J von Blume, A Hausser - FEBS letters, 2019 - Wiley Online Library
In eukaryotic cells, the trans‐Golgi network (TGN) serves as a platform for secretory cargo
sorting and trafficking. In recent years, it has become evident that a complex network of lipid …