[HTML][HTML] The past, present and future of neutralizing antibodies for hepatitis C virus
Hepatitis C virus (HCV) is a major cause of liver disease and hepatocellular carcinoma
worldwide. HCV establishes a chronic infection in the majority of cases. However, some …
worldwide. HCV establishes a chronic infection in the majority of cases. However, some …
The humoral immune response to HCV: understanding is key to vaccine development
SB Cashman, BD Marsden, LB Dustin - Frontiers in immunology, 2014 - frontiersin.org
Hepatitis C virus (HCV) remains a global problem, despite advances in treatment. The low
cost and high benefit of vaccines have made them the backbone of modern public health …
cost and high benefit of vaccines have made them the backbone of modern public health …
[PDF][PDF] Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) can progress from simple steatosis (ie,
nonalcoholic fatty liver [NAFL]) to nonalcoholic steatohepatitis (NASH), cirrhosis, and cancer …
nonalcoholic fatty liver [NAFL]) to nonalcoholic steatohepatitis (NASH), cirrhosis, and cancer …
Human monoclonal antibody HCV1 effectively prevents and treats HCV infection in chimpanzees
TJ Morin, TJ Broering, BA Leav, BM Blair, KJ Rowley… - 2012 - journals.plos.org
Hepatitis C virus (HCV) infection is a leading cause of liver transplantation and there is an
urgent need to develop therapies to reduce rates of HCV infection of transplanted livers …
urgent need to develop therapies to reduce rates of HCV infection of transplanted livers …
Identification and characterization of broadly neutralizing human monoclonal antibodies directed against the E2 envelope glycoprotein of hepatitis C virus
TJ Broering, KA Garrity, NK Boatright, SE Sloan… - Journal of …, 2009 - Am Soc Microbiol
Nearly all livers transplanted into hepatitis C virus (HCV)-positive patients become infected
with HCV, and 10 to 25% of reinfected livers develop cirrhosis within 5 years. Neutralizing …
with HCV, and 10 to 25% of reinfected livers develop cirrhosis within 5 years. Neutralizing …
Structural basis of hepatitis C virus neutralization by broadly neutralizing antibody HCV1
L Kong, E Giang, JB Robbins… - Proceedings of the …, 2012 - National Acad Sciences
Hepatitis C virus (HCV) infects more than 2% of the global population and is a leading cause
of liver cirrhosis, hepatocellular carcinoma, and end-stage liver diseases. Circulating HCV is …
of liver cirrhosis, hepatocellular carcinoma, and end-stage liver diseases. Circulating HCV is …
Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoprotein
Z Keck, W Wang, Y Wang, P Lau, THR Carlsen… - Journal of …, 2013 - Am Soc Microbiol
ABSTRACT A challenge for hepatitis C virus (HCV) vaccine development is defining
conserved epitopes that induce protective antibodies against this highly diverse virus. An …
conserved epitopes that induce protective antibodies against this highly diverse virus. An …
Depletion of interfering antibodies in chronic hepatitis C patients and vaccinated chimpanzees reveals broad cross-genotype neutralizing activity
P Zhang, L Zhong, EB Struble… - Proceedings of the …, 2009 - National Acad Sciences
Using human immune globulins made from antihepatitis C virus (HCV)-positive plasma, we
recently identified two antibody epitopes in the E2 protein at residues 412–426 (epitope I) …
recently identified two antibody epitopes in the E2 protein at residues 412–426 (epitope I) …
Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and …
Cumulative evidence supports a role for neutralizing antibodies contributing to spontaneous
viral clearance during acute hepatitis C virus (HCV) infection. Information on the timing and …
viral clearance during acute hepatitis C virus (HCV) infection. Information on the timing and …
Identification of a broadly cross-reacting and neutralizing human monoclonal antibody directed against the hepatitis C virus E2 protein
Identification of anti-hepatitis C virus (anti-HCV) human antibody clones with broad
neutralizing activity is important for a better understanding of the interplay between the virus …
neutralizing activity is important for a better understanding of the interplay between the virus …