With the advent of antibiotics, bacterial infections were supposed to be a thing of past.
However, this instead led to the selection and evolution of bacteria with mechanisms to …

Bacterial drug resistance has become a global public health threat, among which the
infection of carbapenem-resistant Enterobacterales (CRE) is one of the top noticeable …

Antibiotics are one of the greatest medical advances of the 20th century, however, they are
quickly becoming useless due to antibiotic resistance that has been augmented by poor …

Treating multidrug-resistant infections has increasingly relied on last-resort antibiotics,
including polymyxins, for example colistin. As polymyxins are given routinely, the prevalence …

Background and Aim The emergence of colistin-resistant strains is considered a great threat
for patients with severe infections. Here, we investigate the prevalence and some possible …

Background Mobile colistin resistance (mcr) genes modify Lipid A molecules of the
lipopolysaccharide, changing the overall charge of the outer membrane. Results and …

The global increase in multi-drug-resistant bacteria is severely impacting our ability to
effectively treat common infections. For Gram-negative bacteria, their intrinsic and acquired …

Bacteria and fungi continue to develop new ways to adapt and survive the lethal or biostatic
effects of antimicrobials through myriad mechanisms. Novel antibiotic resistance genes such …

We assessed the prevalence of polymyxin B (PMB)-and tigecycline (TGC)-heteroresistant
Klebsiella pneumoniae isolates and investigated the combined effect of PMB and TGC …

The spread of carbapenem-and polymyxin-resistant Enterobacteriaceae poses a significant
threat to public health, challenging clinicians worldwide with limited therapeutic options. This …