Impact of aging and comorbidities on ischemic stroke outcomes in preclinical animal models: a translational perspective

E Candelario-Jalil, S Paul - Experimental neurology, 2021 - Elsevier
Ischemic stroke is a highly complex and devastating neurological disease. The sudden loss
of blood flow to a brain region due to an ischemic insult leads to severe damage to that area …

Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke

MM Yuen, AM Prabhat, MH Mazurek, IR Chavva… - Science …, 2022 - science.org
Brain imaging is essential to the clinical management of patients with ischemic stroke.
Timely and accessible neuroimaging, however, can be limited in clinical stroke pathways …

Perfusion CT and acute stroke imaging: foundations, applications, and literature review

J Donahue, M Wintermark - Journal of Neuroradiology, 2015 - Elsevier
Multimodal CT features prominently in the rapidly evolving field of acute stroke triage, with
perfusion CT applications at the forefront of many clinical research efforts. Perfusion CT …

Final infarct volume is a stronger predictor of outcome than recanalization in patients with proximal middle cerebral artery occlusion treated with endovascular therapy

SF Zaidi, A Aghaebrahim, X Urra, MA Jumaa… - Stroke, 2012 - Am Heart Assoc
Background and Purpose—The rationale for recanalization therapy in acute ischemic stroke
is to preserve brain through penumbral salvage and thus improve clinical outcomes. We …

Sensitivity of diffusion-and perfusion-weighted imaging for diagnosing acute ischemic stroke is 97.5%

CZ Simonsen, MH Madsen, ML Schmitz, IK Mikkelsen… - Stroke, 2015 - Am Heart Assoc
Background and Purpose—MRI using diffusion-weighted imaging (DWI) is the most
sensitive diagnostic imaging modality for early detection of ischemia, but how accurate is it …

Endovascular treatment for patients with acute stroke who have a large ischemic core and large mismatch imaging profile

LC Rebello, M Bouslama, DC Haussen… - JAMA …, 2017 - jamanetwork.com
Importance Endovascular therapy (ET) is typically not considered for patients with large
baseline ischemic cores (irreversibly injured tissue). Computed tomographic perfusion …

Noninvasive limb remote ischemic preconditioning contributes neuroprotective effects via activation of adenosine A1 receptor and redox status after transient focal …

S Hu, H Dong, H Zhang, S Wang, L Hou, S Chen… - Brain research, 2012 - Elsevier
Purposes: To investigate whether activation of adenosine A1 receptor (A1R) through limb
remote ischemic preconditioning (RIPC) by a noninvasive tourniquet contribute …

High hypoperfusion intensity ratio is independently associated with very poor outcomes in large ischemic core stroke

V Yedavalli, H Adel Salim, DA Lakhani, A Balar… - Clinical …, 2024 - Springer
Background Recent advances have highlighted the efficacy of endovascular thrombectomy
(EVT) in patients with large ischemic core stroke, yet a significant portion still experience …

Younger stroke patients with large pretreatment diffusion-weighted imaging lesions may benefit from endovascular treatment

MD Gilgen, D Klimek, KT Liesirova, J Meisterernst… - Stroke, 2015 - Am Heart Assoc
Background and Purpose—Lesion volume on diffusion-weighted magnetic resonance
imaging (DWI) before acute stroke therapy is a predictor of outcome. Therefore, patients with …

Predictive factors of outcome and hemorrhage after acute ischemic stroke treated by mechanical thrombectomy with a stent-retriever

S Soize, C Barbe, K Kadziolka, L Estrade, I Serre… - Neuroradiology, 2013 - Springer
Introduction The study attempts to identify notable factors predicting poor outcome, death,
and intracranial hemorrhage in patients with acute ischemic stroke undergoing mechanical …