Maternal health during pregnancy plays a major role in shaping health and disease risks in
the offspring. The maternal immune activation hypothesis proposes that inflammatory …

Aim and objective Emerging translational evidence suggests that epigenetic alterations
(DNA methylation, miRNA expression, and histone modifications) occur after external stimuli …

Maternal obesity is associated with increased risk for offspring obesity and non-alcoholic
fatty liver disease (NAFLD), but the causal drivers of this association are unclear. Early …

A successful human pregnancy requires precisely timed adaptations by the maternal
immune system to support fetal growth while simultaneously protecting mother and fetus …

The prevalence of obesity is increasingly common in the United States, with~ 25% of women
of reproductive age being overweight or obese. Metaflammation, a chronic low grade …

Gestational diabetes mellitus (GDM) is a worldwide public health problem affecting up to
27% of pregnancies with high predictive values for childhood obesity and inflammatory …

Maternal mental illness can have a devastating effect during the perinatal period, and has a
profound impact on the care that the baby receives and on the relationships that the baby …

The developing infant gut microbiome affects metabolism, maturation of the gastrointestinal
tract, immune system function, and brain development. Initial seeding of the neonatal …

Leukocyte diversity of the first-trimester maternal-fetal interface has been extensively
described; however, the immunological landscape of the term decidua remains poorly …

Pre-pregnancy (pregravid) obesity has been linked to several adverse health outcomes for
both mother and offspring. Complications during pregnancy include increased risk for …