Vimentin as a multifaceted player and potential therapeutic target in viral infections

I Ramos, K Stamatakis, CL Oeste… - International journal of …, 2020 - mdpi.com
Vimentin is an intermediate filament protein that plays key roles in integration of cytoskeletal
functions, and therefore in basic cellular processes such as cell division and migration …

Mechanical and non‐mechanical functions of filamentous and non‐filamentous vimentin

AE Patteson, A Vahabikashi, RD Goldman… - …, 2020 - Wiley Online Library
Intermediate filaments (IFs) formed by vimentin are less understood than their cytoskeletal
partners, microtubules and F‐actin, but the unique physical properties of IFs, especially their …

Vimentin: from a cytoskeletal protein to a critical modulator of immune response and a target for infection

J Arrindell, B Desnues - Frontiers in Immunology, 2023 - frontiersin.org
Vimentin is an intermediate filament protein that plays a role in cell processes, including cell
migration, cell shape and plasticity, or organelle anchorage. However, studies from over the …

The diverse roles and dynamic rearrangement of vimentin during viral infection

Y Zhang, Z Wen, X Shi, YJ Liu… - Journal of cell …, 2021 - journals.biologists.com
Epidemics caused by viral infections pose a significant global threat. Cytoskeletal vimentin is
a major intermediate filament (IF) protein, and is involved in numerous functions, including …

Host cytoskeletal vimentin serves as a structural organizer and an RNA-binding protein regulator to facilitate Zika viral replication

Y Zhang, S Zhao, Y Li, F Feng, M Li… - Proceedings of the …, 2022 - National Acad Sciences
Emerging microbe infections, such as Zika virus (ZIKV), pose an increasing threat to human
health. Investigations on ZIKV replication have revealed the construction of replication …

The multifaceted roles of NLRP3-modulating proteins in virus infection

J Harris, NA Borg - Frontiers in immunology, 2022 - frontiersin.org
The innate immune response to viruses is critical for the correct establishment of protective
adaptive immunity. Amongst the many pathways involved, the NLRP3 [nucleotide-binding …

Extracellular Vimentin as a Target Against SARS‐CoV‐2 Host Cell Invasion

Ł Suprewicz, M Swoger, S Gupta, E Piktel, FJ Byfield… - Small, 2022 - Wiley Online Library
Infection of human cells by pathogens, including SARS‐CoV‐2, typically proceeds by cell
surface binding to a crucial receptor. The primary receptor for SARS‐CoV‐2 is the …

Vimentin is an important ACE2 co-receptor for SARS-CoV-2 in epithelial cells

J Arrindell, P Abou Atmeh, L Jayet, Y Sereme, JL Mege… - IScience, 2022 - cell.com
Vimentin is a type III intermediate filament protein, widely expressed in mesenchymal cells.
Mainly located in the cytoplasm, vimentin can also appear at extracellular locations, where it …

The molecular biophysics of extracellular vimentin and its role in pathogen–host interactions

S Parvanian, LS Coelho-Rato, JE Eriksson… - Current Opinion in Cell …, 2023 - Elsevier
Vimentin, an intermediate filament protein typically located in the cytoplasm of mesenchymal
cells, can also be secreted as an extracellular protein. The organization of extracellular …

Intracellular vimentin regulates the formation of classical swine fever virus replication complex through interaction with NS5A protein

Y Cheng, J Lou, Y Liu, C Liu, J Chen, M Yang… - Journal of …, 2023 - Am Soc Microbiol
Vimentin (VIM), an indispensable protein, is responsible for the formation of intermediate
filament structures within cells and plays a crucial role in viral infections. However, the …