Gene–environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism
Psychiatric phenotypes are multifactorial and polygenic, resulting from the complex interplay
of genes and environmental factors that act cumulatively throughout an organism's lifetime …
of genes and environmental factors that act cumulatively throughout an organism's lifetime …
The FKBP51 glucocorticoid receptor co-chaperone: regulation, function, and implications in health and disease
Among the chaperones and co-chaperones regulating the glucocorticoid receptor (GR),
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …
SAFit2 reduces neuroinflammation and ameliorates nerve injury-induced neuropathic pain
S Wedel, P Mathoor, O Rauh, T Heymann… - Journal of …, 2022 - Springer
Background Neuropathic pain is experienced worldwide by patients suffering from nerve
injuries, infectious or metabolic diseases or chemotherapy. However, the treatment options …
injuries, infectious or metabolic diseases or chemotherapy. However, the treatment options …
Checks and balances: The glucocorticoid receptor and NFĸB in good times and bad
Mutual regulation and balance between the endocrine and immune systems facilitate an
organism's stress response and are impaired following chronic stress or prolonged immune …
organism's stress response and are impaired following chronic stress or prolonged immune …
FK506-binding proteins and their diverse functions
M Tong, Y Jiang - Current molecular pharmacology, 2016 - ingentaconnect.com
FK506 binding proteins (FKBPs) are a family of highly conserved proteins in eukaryotes. The
prototype of this protein family, FKBP12, is the binding partner for immunosuppressive drugs …
prototype of this protein family, FKBP12, is the binding partner for immunosuppressive drugs …
Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency
Single nucleotide polymorphisms (SNPs) in the FK506 binding protein 5 (FKBP5) gene
combine with traumatic events to increase risk for post-traumatic stress and major …
combine with traumatic events to increase risk for post-traumatic stress and major …
Interleukin-8 in melanoma pathogenesis, prognosis and therapy—an integrated view into other neoplasms and chemokine networks
A Filimon, IA Preda, AF Boloca, G Negroiu - Cells, 2021 - mdpi.com
Cutaneous melanoma accounts for only about 7% of skin cancers but is causing almost 90%
of deaths. Melanoma cells have a distinct repertoire of mutations from other cancers, a high …
of deaths. Melanoma cells have a distinct repertoire of mutations from other cancers, a high …
Multidomain peptidyl prolyl cis/trans isomerases
C Schiene-Fischer - Biochimica et Biophysica Acta (BBA)-General Subjects, 2015 - Elsevier
Background Peptidyl prolyl cis/trans isomerases (PPIases) assist the folding and
restructuring of client proteins by catalysis of the slow rotational motion of peptide bonds …
restructuring of client proteins by catalysis of the slow rotational motion of peptide bonds …
FK506 binding protein 51 integrates pathways of adaptation: FKBP51 shapes the reactivity to environmental change
T Rein - Bioessays, 2016 - Wiley Online Library
This review portraits FK506 binding protein (FKBP) 51 as “reactivity protein” and collates
recent publications to develop the concept of FKBP51 as contributor to different levels of …
recent publications to develop the concept of FKBP51 as contributor to different levels of …
Interleukin-8 is a key mediator of FKBP51-induced melanoma growth, angiogenesis and metastasis
Background: FKBP51 is overexpressed in melanoma and impacts tumour cell properties.
However, its comprehensive role in melanoma pathogenesis and underlying mechanism (s) …
However, its comprehensive role in melanoma pathogenesis and underlying mechanism (s) …