[HTML][HTML] Strategies of functionalized GelMA-based bioinks for bone regeneration: Recent advances and future perspectives

Y Zhu, X Yu, H Liu, J Li, M Gholipourmalekabadi, K Lin… - Bioactive Materials, 2024 - Elsevier
Gelatin methacryloyl (GelMA) hydrogels is a widely used bioink because of its good
biological properties and tunable physicochemical properties, which has been widely used …

p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells

J Majewska, A Agrawal, A Mayo, L Roitman… - Nature Cell …, 2024 - nature.com
The accumulation of senescent cells promotes ageing and age-related diseases, but
molecular mechanisms that senescent cells use to evade immune clearance and …

Immune therapeutic strategies for the senescent tumor microenvironment

T Yasuda, Y Alan Wang - British Journal of Cancer, 2024 - nature.com
Senescent cells can either to promote immunosuppressive tumor microenvironment or
facilitate immune surveillance. Despite the revolutionary impact of cancer immunotherapy …

Brain macrophage senescence in glioma

L Li, T Zhang, M Xiao, Y Lu, L Gao - Seminars in Cancer Biology, 2024 - Elsevier
Gliomas are a diverse group of primary central nervous system neoplasms with no curative
therapies available. Brain macrophages comprise microglia in the brain parenchyma, border …

[HTML][HTML] DAMPs in immunosenescence and cancer

F Chen, H Tang, X Cai, J Lin, R Kang, D Tang… - Seminars in Cancer …, 2024 - Elsevier
Damage-associated molecular patterns (DAMPs) are endogenous molecules released by
cells in response to injury or stress, recognized by host pattern recognition receptors that …

Integrated-omics profiling unveils the disparities of host defense to ECM scaffolds during wound healing in aged individuals

S Chen, C Chu, C Wang, Y Yang, Z Xu, Y Qu, Y Man - Biomaterials, 2024 - Elsevier
Extracellular matrix (ECM) scaffold membranes have exhibited promising potential to better
the outcomes of wound healing by creating a regenerative microenvironment around …

[HTML][HTML] Immune Alterations with Aging: Mechanisms and Intervention Strategies

W Yu, Y Yu, S Sun, C Lu, J Zhai, Y Lei, F Bai, R Wang… - Nutrients, 2024 - mdpi.com
Aging is the result of a complex interplay of physical, environmental, and social factors,
leading to an increased prevalence of chronic age-related diseases that burden health and …

[HTML][HTML] Influence of Donor-Specific Characteristics on Cytokine Responses in H3N2 Influenza A Virus Infection: New Insights from an Ex Vivo Model

CG Huang, MJ Hsieh, YC Wu, PW Huang… - International Journal of …, 2024 - mdpi.com
Influenza A virus (IAV) is known for causing seasonal epidemics ranging from flu to more
severe outcomes like pneumonia, cytokine storms, and acute respiratory distress syndrome …

IL-4-ever young: Type 2 cytokine signaling in macrophages slows aging

CM Finlay, JE Allen - Immunity, 2024 - Elsevier
Macrophages activated via the IL-4 receptor possess non-immune functions that support
tissue homeostasis, but their specific role in aging is unknown. In this issue of Immunity …

Comprehensive landscapes of the causal network between immunity and sarcopenia

M Liu, J Wang, Y Han, X Fu, Y Pan, C Yang… - Frontiers in …, 2024 - frontiersin.org
Background Inflammaging, an immune status characterized by a sustained increase in pro-
inflammatory markers and a decline in anti-inflammatory mechanisms, is a critical risk factor …