Sex differences in diseases involving oxidative and proteolytic stress are common, including
greater ischemic heart disease, Parkinson disease and stroke in men, and greater …

Background Female sex has been included as a risk factor in models developed to predict
the risk of acute kidney injury (AKI) associated with cardiac surgery, aminoglycoside …

Female mice are much more resistant to ischemia/reperfusion (I/R)-induced kidney injury
when compared with males. Although estrogen administration can partially reduce kidney …

Ischemia-reperfusion induced acute kidney injury (IR-AKI) is widely used as a model of AKI
in mice, but results are often quite variable with high, often unreported mortality rates that …

Autosomal dominant polycystic kidney disease (ADPKD) affects an estimated 1 in 1,000
people and slowly progresses to end-stage renal disease (ESRD) in about half of these …

Experimentally, females show an improved ability to recover from ischemia-reperfusion
injury (IRI) compared with males; however, this sex-dependent response is less established …

Background Female sex has been included as a risk factor in models developed to predict
the development of AKI. In addition, the commentary to the Kidney Disease Improving Global …

Background The association of several comorbidities, including diabetes mellitus,
hypertension, cardiovascular disease, heart failure and chronic kidney or liver disease, with …

Unilateral ureteral obstruction (UUO) is an animal rodent model that allows the study of
obstructive nephropathy in an accelerated manner. During UUO, tubular damage is induced …

Emerging evidence suggests that renal endothelial function may be altered in ischemia-
reperfusion injury. Acute kidney injury is sexually dimorphic, and estrogen protects renal …