The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Cancer microenvironment is critical for tumorigenesis and cancer progression. The
extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells …

The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of
solid tumours that plays a crucial role in shaping their progression. Many desmoplastic …

Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

Simple Summary Matrix stiffness is recognized as a critical factor in cancer progression.
Recent studies have shown that matrix stiffening is caused by the accumulation, contraction …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Integrin-dependent adhesion to the extracellular matrix (ECM) mediates mechanosensing
and signaling in response to altered microenvironmental conditions. In order to provide …

NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was
identified as a pivotal pathway in mediating inflammatory responses. However, with …

Simple Summary Triple Negative Breast Cancer represents a cancer type with an unmet
clinical need. This type of breast cancer presents the worse clinical outcome due to its …

Resistance to antitumor treatment contributes to patient mortality. Functional proteomic
screening of organoids derived from chemotherapy-treated patients with breast cancer …