Cellular crosstalk between endothelial and smooth muscle cells in vascular wall remodeling

N Méndez-Barbero, C Gutiérrez-Muñoz… - International journal of …, 2021 - mdpi.com
Pathological vascular wall remodeling refers to the structural and functional changes of the
vessel wall that occur in response to injury that eventually leads to cardiovascular disease …

Recent Progress in in vitro Models for Atherosclerosis Studies

J Chen, X Zhang, R Millican, T Lynd… - Frontiers in …, 2022 - frontiersin.org
Atherosclerosis is the primary cause of hardening and narrowing arteries, leading to
cardiovascular disease accounting for the high mortality in the United States. For developing …

3D in vitro M2 macrophage model to mimic modulation of tissue repair

J Sapudom, S Karaman, WKE Mohamed… - npj Regenerative …, 2021 - nature.com
Distinct anti-inflammatory macrophage (M2) subtypes, namely M2a and M2c, are reported to
modulate the tissue repair process tightly and chronologically by modulating fibroblast …

Collagen fibril orientation instructs fibroblast differentiation via cell contractility

J Sapudom, S Karaman, BC Quartey… - Advanced …, 2023 - Wiley Online Library
Collagen alignment is one of the key microarchitectural signatures of many pathological
conditions, including scarring and fibrosis. Investigating how collagen alignment modulates …

May the force be with you (or not): The immune system under microgravity

M ElGindi, J Sapudom, IH Ibrahim, M Al-Sayegh… - Cells, 2021 - mdpi.com
All terrestrial organisms have evolved and adapted to thrive under Earth's gravitational force.
Due to the increase of crewed space flights in recent years, it is vital to understand how the …

Modeling adipogenesis: current and future perspective

HF Bahmad, R Daouk, J Azar, J Sapudom, JCM Teo… - Cells, 2020 - mdpi.com
Adipose tissue is contemplated as a dynamic organ that plays key roles in the human body.
Adipogenesis is the process by which adipocytes develop from adipose-derived stem cells …

3D tissue-engineered vascular drug screening platforms: promise and considerations

I Marei, T Abu Samaan, MA Al-Quradaghi… - Frontiers in …, 2022 - frontiersin.org
Despite the efforts devoted to drug discovery and development, the number of new drug
approvals have been decreasing. Specifically, cardiovascular developments have been …

Preclinical in vitro evaluation of implantable materials: conventional approaches, new models and future directions

E Frisch, L Clavier, A Belhamdi, NE Vrana… - … in Bioengineering and …, 2023 - frontiersin.org
Nowadays, implants and prostheses are widely used to repair damaged tissues or to treat
different diseases, but their use is associated with the risk of infection, inflammation and …

Effects of an aged tissue niche on the immune potency of dendritic cells using simulated microgravity

M ElGindi, J Sapudom, A Garcia Sabate… - npj Aging, 2023 - nature.com
Microgravity accelerates the aging of various physiological systems, and it is well
acknowledged that aged individuals and astronauts both have increased susceptibility to …

Identification and Validation of Candidate Gene Module Along With Immune Cells Infiltration Patterns in Atherosclerosis Progression to Plaque Rupture via …

J Xu, C Chen, Y Yang - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Objective To explore the differentially expressed genes (DEGs) along with infiltrating
immune cells landscape and their potential mechanisms in the progression of …