Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …

Carbon monoxide (CO) is continuously produced in mammalian cells during the
degradation of heme. It is a stable gaseous molecule that reacts selectively with transition …

Carbon monoxide (CO) is an endogenously produced gaseous signaling molecule with
demonstrated pharmacological effects. In studying CO biology, three delivery forms have …

The first descriptions of carbon monoxide (CO) and its toxic nature appeared in the literature
over 100 years ago in separate publications by Drs. Douglas and Haldane. Both men …

Carbon monoxide (CO) has been firmly established as an endogenous signaling molecule
with a variety of pathophysiological and pharmacological functions, including …

Carbon monoxide (CO) is an endogenously produced gas that has gained recognition as a
biological signal transduction effector with properties similar, but not identical, to that of nitric …

The possibility of a" post-antibiotic era" in the 21st century, in which common infections may
kill, has prompted research into radically new antimicrobials. CO-releasing molecules …

Carbon monoxide is rapidly emerging as an important cellular messenger, regulating a wide
range of physiological processes. Crucial to its role in both physiology and disease is its …

Background Genetic overexpression or pharmacological activation of heme oxygenase (HO)
are identified as potential therapeutic target for spinal cord injury (SCI); however, the role of …

Carbon monoxide (CO), like nitric oxide (NO), is an essential signalling molecule in humans.
It is active in the cardiovascular system as a vasodilator. In addition, CO possesses anti …