Host factors in coronavirus replication
AH De Wilde, EJ Snijder, M Kikkert… - Roles of host gene and …, 2018 - Springer
Coronaviruses are pathogens with a serious impact on human and animal health. They
mostly cause enteric or respiratory disease, which can be severe and life threatening, eg, in …
mostly cause enteric or respiratory disease, which can be severe and life threatening, eg, in …
Viral evasion of intracellular DNA and RNA sensing
The co-evolution of viruses with their hosts has led to the emergence of viral pathogens that
are adept at evading or actively suppressing host immunity. Pattern recognition receptors …
are adept at evading or actively suppressing host immunity. Pattern recognition receptors …
Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-like protease
BT Freitas, IA Durie, J Murray, JE Longo… - ACS infectious …, 2020 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent for
COVID-19, is a novel human betacoronavirus that is rapidly spreading worldwide. The …
COVID-19, is a novel human betacoronavirus that is rapidly spreading worldwide. The …
MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment
AH de Wilde, VS Raj, D Oudshoorn… - Journal of General …, 2013 - microbiologyresearch.org
Coronavirus (CoV) infections are commonly associated with respiratory and enteric disease
in humans and animals. The 2003 outbreak of severe acute respiratory syndrome (SARS) …
in humans and animals. The 2003 outbreak of severe acute respiratory syndrome (SARS) …
Arterivirus molecular biology and pathogenesis
EJ Snijder, M Kikkert, Y Fang - Journal of General …, 2013 - microbiologyresearch.org
Arteriviruses are positive-stranded RNA viruses that infect mammals. They can cause
persistent or asymptomatic infections, but also acute disease associated with a respiratory …
persistent or asymptomatic infections, but also acute disease associated with a respiratory …
SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex
X Chen, X Yang, Y Zheng, Y Yang, Y Xing… - Protein & cell, 2014 - academic.oup.com
SARS coronavirus (SARS-CoV) develops an antagonistic mechanism by which to evade the
antiviral activities of interferon (IFN). Previous studies suggested that SARS-CoV papain-like …
antiviral activities of interferon (IFN). Previous studies suggested that SARS-CoV papain-like …
[HTML][HTML] ISG15: it's complicated
JV Dzimianski, FEM Scholte, É Bergeron… - Journal of molecular …, 2019 - Elsevier
Interferon-stimulated gene product 15 (ISG15) is a key component of host responses to
microbial infection. Despite having been known for four decades, grasping the functions and …
microbial infection. Despite having been known for four decades, grasping the functions and …
[HTML][HTML] MERS-CoV papain-like protease has deISGylating and deubiquitinating activities
Coronaviruses encode papain-like proteases (PLpro) that are often multifunctional enzymes
with protease activity to process the viral replicase polyprotein and deubiquitinating …
with protease activity to process the viral replicase polyprotein and deubiquitinating …
Structural basis for the ubiquitin-linkage specificity and deISGylating activity of SARS-CoV papain-like protease
Severe acute respiratory syndrome coronavirus (SARS-CoV) encodes a papain-like
protease (PLpro) with both deubiquitinating (DUB) and deISGylating activities that are …
protease (PLpro) with both deubiquitinating (DUB) and deISGylating activities that are …
ISG15: its roles in SARS-CoV-2 and other viral infections
Abstract Interferon (IFN)-stimulated gene 15 (ISG15), a ubiquitin-like pleiotropic protein and
one of the most abundant ISGs, has been studied extensively; however, its roles in SARS …
one of the most abundant ISGs, has been studied extensively; however, its roles in SARS …