The impact of rare protein coding genetic variation on adult cognitive function

CY Chen, R Tian, T Ge, M Lam, G Sanchez-Andrade… - Nature Genetics, 2023 - nature.com
Compelling evidence suggests that human cognitive function is strongly influenced by
genetics. Here, we conduct a large-scale exome study to examine whether rare protein …

Cognitive processing speed and accuracy are intrinsically different in genetic architecture and brain phenotypes

M Li, X Dang, Y Chen, Z Chen, X Xu, Z Zhao… - Nature …, 2024 - nature.com
Since the birth of cognitive science, researchers have used reaction time and accuracy to
measure cognitive ability. Although recognition of these two measures is often based on …

SATB2 organizes the 3D genome architecture of cognition in cortical neurons

N Wahl, S Espeso-Gil, P Chietera, A Nagel… - Molecular Cell, 2024 - cell.com
The DNA-binding protein SATB2 is genetically linked to human intelligence. We studied its
influence on the three-dimensional (3D) epigenome by mapping chromatin interactions and …

[HTML][HTML] Large-Scale Mendelian Randomization Study Reveals Circulating Blood-based Proteomic Biomarkers for Psychopathology and Cognitive Task Performance

U Bhattacharyya, J John, M Lam, J Fisher, B Sun… - medRxiv, 2024 - ncbi.nlm.nih.gov
Background: Research on peripheral (eg, blood-based) biomarkers for psychiatric illness
has typically been low-throughput in terms of both the number of subjects and the range of …

[HTML][HTML] Dissecting Schizophrenia Biology Using Pleiotropy with Cognitive Genomics

U Bhattacharyya, J John, T Lencz, M Lam - medRxiv, 2024 - ncbi.nlm.nih.gov
Given the increasingly large number of loci discovered by psychiatric GWAS, specification of
the key biological pathways underlying these loci has become a priority for the field. We …

The Etiology of Executive Functioning Is Nature and Nurture

AS Hatoum - Biological Psychiatry, 2023 - biologicalpsychiatryjournal.com
Executive functions (EFs) are higher-order cognitive control processes that influence and
direct thoughts and cognitive processes. These include the ability to flexibly shift between …