Modular polyketide synthases (PKSs) run catalytic reactions over dozens of steps in a highly
orchestrated manner. To accomplish this synthetic feat, they form megadalton multienzyme …

The modular polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs)
are among the largest and most complicated enzymes in nature. In these biosynthetic …

Polyketide natural products constitute a broad class of compounds with diverse structural
features and biological activities. Their biosynthetic machinery, represented by type I …

Type I modular polyketide synthases are homodimeric multidomain assembly line enzymes
that synthesize a variety of polyketide natural products by performing polyketide chain …

Highlights•High and low-resolution analysis yields insight into modular architecture of
PKSs.•Energetic coupling of chain elongation controls channeling of intermediates.•Protein …

Covering: mid 1990s to 2018 Over the last two decades, diverse approaches have been
explored to generate new polyketides by engineering polyketide synthases (PKSs) …

Covering: up to early 2018 Polyketides and nonribosomal peptides are two major families of
natural product with a broad range of biological activities. Polyketide synthases (PKSs) …

Covering: 2006 to 2015 Most of the stereocenters of polyketide natural products are
established during assembly line biosynthesis. The body of knowledge for how …

Nonribosomal peptide synthetases (NRPSs) are large modular enzymes that synthesize
secondary metabolites and natural product therapeutics. Most NRPS biosynthetic pathways …

Modular type I polyketide synthases (PKSs) are versatile biosynthetic systems that initiate,
successively elongate, and modify acyl chains. Intermediate transfer between modules is …