Pubertal timing is regulated by the complex interplay of genetic, environmental, nutritional
and epigenetic factors. Criteria for determining normal pubertal timing, and thus the …

Puberty is programmed through a multifactorial gene network which works to activate the
pulsatile secretion of the gonadotropin releasing hormone (GnRH), and subsequently …

Context Loss-of-function mutations of makorin RING finger protein 3 (MKRN3) are the most
common monogenic cause of familial central precocious puberty (CPP). Objective To …

Pubertal onset is known to result from reactivation of the hypothalamic-pituitary-gonadal
(HPG) axis, which is controlled by complex interactions of genetic and nongenetic factors …

Central precocious puberty (CPP) is a condition in which the hypothalamus–pituitary–
gonadal system is activated earlier than the normal developmental stage. The etiology …

Background Central precocious puberty (CPP) due to premature activation of GnRH
secretion results in early epiphyseal fusion and to a significant compromise in the achieved …

Makorin RING finger protein 3 (MKRN3) is a key inhibitor of the hypothalamic–pituitary–
gonadal axis. Loss-of-function mutations in MKRN3 cause familial and sporadic central …

Puberty is a critical process characterized by several physical and psychological changes
that culminate in the achievement of sexual maturation and fertility. The onset of puberty …

Background Paternally inherited loss-of-function mutations in MKRN3 underlie central
precocious puberty (CPP). We describe clinical and genetic features of CPP patients with …

Abstract Context Defects in MKRN3, DLK1, KISS1, and KISS1R and some disorders, such
as Temple syndrome (TS14), cause central precocious puberty (CPP). Recently, pathogenic …