Synthetic alternatives to Matrigel

EA Aisenbrey, WL Murphy - Nature Reviews Materials, 2020 - nature.com
Matrigel, a basement-membrane matrix extracted from Engelbreth–Holm–Swarm mouse
sarcomas, has been used for more than four decades for a myriad of cell-culture …

Impact of cryopreservation and freeze-thawing on therapeutic properties of mesenchymal stromal/stem cells and other common cellular therapeutics

C Cottle, AP Porter, A Lipat, C Turner-Lyles… - Current stem cell …, 2022 - Springer
Abstract Purpose of Review Cryopreservation and its associated freezing and thawing
procedures–short “freeze-thawing”–are among the final steps in economically viable …

Cellular reprogramming and epigenetic rejuvenation

DJ Simpson, NN Olova, T Chandra - Clinical epigenetics, 2021 - Springer
Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the
generation of induced pluripotent stem cells, have delivered preliminary evidence that …

[HTML][HTML] Cardiovascular disease models: a game changing paradigm in drug discovery and screening

H Savoji, MH Mohammadi, N Rafatian, MK Toroghi… - Biomaterials, 2019 - Elsevier
Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …

Effect of Freeze‐Drying on Apple Pomace and Pomegranate Peel Powders Used as a Source of Bioactive Ingredients for the Development of Functional Yogurt

M Ahmed, A Ali, A Sarfraz, Q Hong… - Journal of Food …, 2022 - Wiley Online Library
Agro‐industrial by‐products of fruits have turned into an essential source of bioactive
products. This study examined the effect of freeze‐drying on apple pomace powder (APP) …

MSCs vs. iPSCs: Potential in therapeutic applications

K Thanaskody, AS Jusop, GJ Tye… - Frontiers in Cell and …, 2022 - frontiersin.org
Over the past 2 decades, mesenchymal stem cells (MSCs) have attracted a lot of interest as
a unique therapeutic approach for a variety of diseases. MSCs are capable of self-renewal …

The potential and limitations of induced pluripotent stem cells to achieve wound healing

J Gorecka, V Kostiuk, A Fereydooni, L Gonzalez… - Stem cell research & …, 2019 - Springer
Wound healing is the physiologic response to a disruption in normal skin architecture and
requires both spatial and temporal coordination of multiple cell types and cytokines. This …

Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity

N Olova, DJ Simpson, RE Marioni, T Chandra - Aging cell, 2019 - Wiley Online Library
Induced pluripotent stem cells (IPSCs), with their unlimited regenerative capacity, carry the
promise for tissue replacement to counter age‐related decline. However, attempts to realize …

Brain-on-a-chip: A history of development and future perspective

S Bang, S Jeong, N Choi, HN Kim - Biomicrofluidics, 2019 - pubs.aip.org
Since the advent of organ-on-a-chip, many researchers have tried to mimic the physiology of
human tissue on an engineered platform. In the case of brain tissue, structural connections …

Strategies to optimize adult stem cell therapy for tissue regeneration

S Liu, J Zhou, X Zhang, Y Liu, J Chen, B Hu… - International journal of …, 2016 - mdpi.com
Stem cell therapy aims to replace damaged or aged cells with healthy functioning cells in
congenital defects, tissue injuries, autoimmune disorders, and neurogenic degenerative …