The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections

KB Rombouts, TAR van Merrienboer… - European journal of …, 2022 - Wiley Online Library
Background Aortic aneurysms (AA) are pathological dilations of the aorta, associated with
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …

7-Ketocholesterol and 7β-hydroxycholesterol: In vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity

A Vejux, D Abed-Vieillard, K Hajji, A Zarrouk… - Biochemical …, 2020 - Elsevier
Oxysterols are molecules derived by the oxidation of cholesterol and can be formed either
by auto-oxidation, enzymatically or by both processes. Among the oxysterols formed by auto …

Enhanced endoplasmic reticulum and mitochondrial stress in abdominal aortic aneurysm

M Navas-Madroñal, C Rodriguez, M Kassan… - Clinical …, 2019 - portlandpress.com
Abdominal aortic aneurysm (AAA) is a degenerative vascular disease with a complex
aetiology that remains to be fully elucidated. Clinical management of AAA is limited to …

[HTML][HTML] 7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells

MC Chang, YJ Chen, EJW Liou, WY Tseng, CP Chan… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Cardiovascular diseases (atherosclerosis, stroke, myocardiac infarction etc.) are the major
systemic diseases of elder peoples in the world. This is possibly due to increased levels of …

Molecular pathogenesis of genetic and sporadic aortic aneurysms and dissections

YH Shen, SA LeMaire - Current problems in surgery, 2017 - Elsevier
The aorta is the largest artery and can be divided into several segments (Fig 1). The
diaphragm divides the aorta into the thoracic and abdominal aorta. The thoracic aorta …

Influence of drying temperatures on the quality of pasta formulated with different egg products

V Verardo, Y Riciputi, MC Messia, E Marconi… - … Food Research and …, 2017 - Springer
The effect of egg products and drying temperatures on dried egg pasta quality has been
considered. Two diagrams of temperature and three egg products were used to develop …

A palladium (II)–saccharinate complex of terpyridine exerts higher anticancer potency and less toxicity than cisplatin in a mouse allograft model

Y Cetin, Z Adiguzel, HU Polat, T Akkoc, A Tas… - Anti-Cancer …, 2017 - journals.lww.com
The main aim of this study is to assess the safety and antitumor efficacy of a palladium
(II)(Pd)–saccharinate complex with terpyridine. To characterize the Pd (II) complex in vitro, its …

[HTML][HTML] 25-hydroxycholesterol down-regulates oxysterol binding protein like 2 (OSBPL2) via the p53/SREBF2/NFYA signaling pathway

Q Wang, C Lin, C Zhang, H Wang, Y Lu, J Yao… - The Journal of Steroid …, 2019 - Elsevier
Abstract Oxysterol Binding Protein Like 2 (OSBPL2) is a lipid-binding protein implicated in
various cellular processes. Previous studies have shown that depression of OSBPL2 …

A platinum blue complex exerts its cytotoxic activity via DNA damage and induces apoptosis in cancer cells

Z Adiguzel, S Ozalp‐Yaman, G Celik… - Chemical Biology & …, 2017 - Wiley Online Library
Here, we describe the characteristics of a Pt‐blue complex [Pt4 (2‐atp) 8 (H2O)(OH)](2‐atp:
2‐aminothiophenol) as a prodrug for its DNA‐binding properties and its use in cancer …

Reactive oxygen species in cardiovascular diseases: An update

J Fei, LJ Demillard, J Ren - Exploration of Medicine, 2022 - explorationpub.com
Cardiovascular diseases are among the leading causes of death worldwide, imposing major
health threats. Reactive oxygen species (ROS) are one of the most important products from …