[HTML][HTML] Dysregulation of miRNAs in Soft Tissue Sarcomas
S Zoroddu, A Lucariello, A De Luca, L Bagella - Cells, 2024 - mdpi.com
MicroRNAs (miRNAs) are pivotal regulators of gene expression, influencing key cellular
processes such as proliferation, differentiation, apoptosis, and metastasis. In the realm of …
processes such as proliferation, differentiation, apoptosis, and metastasis. In the realm of …
Improving anti-tumor efficacy of low-dose Vincristine in rhabdomyosarcoma via the combination therapy with FOXM1 inhibitor RCM1
Rhabdomyosarcoma (RMS) is a highly metastatic soft-tissue sarcoma that often develops
resistance to current therapies, including vincristine. Since the existing treatments have not …
resistance to current therapies, including vincristine. Since the existing treatments have not …
Hyperactive Akt1 signaling increases tumor progression and DNA repair in embryonal rhabdomyosarcoma RD line and confers susceptibility to glycolysis and …
In pediatric rhabdomyosarcoma (RMS), elevated Akt signaling is associated with increased
malignancy. Here, we report that expression of a constitutively active, myristoylated form of …
malignancy. Here, we report that expression of a constitutively active, myristoylated form of …
Platinum-Based Regimens Are Active in Advanced Pediatric-Type Rhabdomyosarcoma in Adults and Depending on HMGB1 Expression
N Hindi, J Carrillo-García, E Blanco-Alcaina… - International journal of …, 2023 - mdpi.com
Rhabdomyosarcoma (RMS) in adults is a rare and aggressive disease, which lacks
standard therapies for relapsed or advanced disease. This retrospective study aimed to …
standard therapies for relapsed or advanced disease. This retrospective study aimed to …
Deciphering the genomic landscape and pharmacological profile of uncommon entities of adult rhabdomyosarcomas
Adult rhabdomyosarcoma (RMS) represents an uncommon entity with an incidence of less
than 3% of all soft tissue sarcomas (STS). Consequently, the natural history and the clinical …
than 3% of all soft tissue sarcomas (STS). Consequently, the natural history and the clinical …
Myogenetic oligodeoxynucleotides as anti-nucleolin aptamers inhibit the growth of embryonal rhabdomyosarcoma cells
N Nohira, S Shinji, S Nakamura, Y Nihashi… - Biomedicines, 2022 - mdpi.com
Embryonal rhabdomyosarcoma (ERMS) is the muscle-derived tumor retaining myogenic
ability. iSN04 and AS1411, which are myogenetic oligodeoxynucleotides (myoDNs) serving …
ability. iSN04 and AS1411, which are myogenetic oligodeoxynucleotides (myoDNs) serving …
Loss of Chemerin in Rhabdomyosarcoma Cells Polarizes Adjacent Monocytes to an Immunosuppressive Phenotype
R Sun, JL Lin, MS Cheng, KY Lee, T Spruss… - Biomedicines, 2022 - mdpi.com
Chemerin is a multifunctional adipokine that regulates adipogenesis, insulin signaling and
blood pressure and has thus a central function in metabolism. Mounting evidence confirmed …
blood pressure and has thus a central function in metabolism. Mounting evidence confirmed …
Case Report: An NTRK1 fusion-positive embryonal rhabdomyosarcoma: clinical presentations, pathological characteristics and genotypic analyses
NM Li, SH Jiang, P Zhou, XH Li - Frontiers in Oncology, 2023 - frontiersin.org
Rhabdomyosarcoma (RMS) is a prevalent form of soft tissue sarcoma that primarily affects
children. Pediatric RMS is characterized by two distinct histological variants: embryonal …
children. Pediatric RMS is characterized by two distinct histological variants: embryonal …