Perinatal brain injury remains a major cause of death and life-long disability. Perinatal brain
injury is typically associated with hypoxia-ischemia and/or infection/inflammation. Both …

Each year, more than two million babies die or evolve to permanent invalidating sequelae
worldwide because of Hypoxic-Ischemic Brain Injury (HIBI). There is no current treatment for …

Applications of RNA interference for neuroscience research have been limited by a lack of
simple and efficient methods to deliver oligonucleotides to primary neurons in culture and to …

Background and purpose: Currently there is no effective treatment for neonatal arterial
ischemic stroke (AIS). Cannabidiol (CBD) is neuroprotective in models of newborn hypoxic …

Background Neuroinflammation plays an important role in neonatal hypoxic-ischemic
encephalopathy (HIE). Although microglia are largely responsible for injury-induced …

Background Neuroinflammation plays an important role in ischemic brain injury and
recovery, however the interplay between brain development and the neuroinflammatory …

During acute neuroinflammation, increased levels of cytokines within the brain may
contribute to synaptic reorganization that results in long-term changes in network …

Neonatal hypoxic-ischemic (HI) encephalopathy is a severe disease for which there is
currently no curative treatment. Recent evidence suggests that high-mobility group box 1 …

Elevated microglial/macrophage-associated biomarkers in the cerebrospinal fluid of infant
victims of abusive head trauma (AHT) suggest that these cells play a role in the …

Hypoxic-ischemic encephalopathy is brain injury resulting from the loss of oxygen and blood
supply around the time of birth. It is associated with a high risk of death or disability. The only …