Novel cannabinoid receptors
AJ Brown - British journal of pharmacology, 2007 - Wiley Online Library
Cannabinoids have numerous physiological effects. In the years since the molecular
identification of the G protein‐coupled receptors CB1 and CB2, the ion channel TRPV1, and …
identification of the G protein‐coupled receptors CB1 and CB2, the ion channel TRPV1, and …
Sphingosine-1-phosphate and its receptors: structure, signaling, and influence
The sphingosine-1-phosphate (S1P) receptor signaling system has biological and medical
importance and is the first lipid G protein–coupled receptor (GPCR) structure to be solved to …
importance and is the first lipid G protein–coupled receptor (GPCR) structure to be solved to …
Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate
Lysophospholipids are bioactive lipids and can signal through G-protein-coupled receptors
(GPCRs). The best studied lysophospholipids are lysophosphatidic acid (LPA) and …
(GPCRs). The best studied lysophospholipids are lysophosphatidic acid (LPA) and …
Evolutionary origins of the endocannabinoid system
Endocannabinoid system evolution was estimated by searching for functional orthologs in
the genomes of twelve phylogenetically diverse organisms: Homo sapiens, Mus musculus …
the genomes of twelve phylogenetically diverse organisms: Homo sapiens, Mus musculus …
Aiming drug discovery at lysophosphatidic acid targets
G Tigyi - British journal of pharmacology, 2010 - Wiley Online Library
Lysophosphatidic acid (LPA, 1‐radyl‐2‐hydroxy‐sn‐glycero‐3‐phosphate) is the prototype
member of a family of lipid mediators and second messengers. LPA and its naturally …
member of a family of lipid mediators and second messengers. LPA and its naturally …
Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo
H Zhang, X Xu, J Gajewiak, R Tsukahara, Y Fujiwara… - Cancer research, 2009 - AACR
Signal transduction modifiers that modulate the lysophosphatidic acid (LPA) pathway have
potential as anticancer agents. Herein, we describe metabolically stabilized LPA analogues …
potential as anticancer agents. Herein, we describe metabolically stabilized LPA analogues …
Targeted deletion of LPA5 identifies novel roles for lysophosphatidic acid signaling in development of neuropathic pain
ME Lin, RR Rivera, J Chun - Journal of Biological Chemistry, 2012 - ASBMB
Lysophosphatidic acid (LPA) is a bioactive lipid that serves as an extracellular signaling
molecule acting through cognate G protein-coupled receptors designated LPA 1–6 that …
molecule acting through cognate G protein-coupled receptors designated LPA 1–6 that …
Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation
Lysophosphatidic acid (LPA) is a ligand for LPA 1–3 of the endothelial differentiation gene
family G-protein-coupled receptors, and LPA 4–8 is related to the purinergic family G-protein …
family G-protein-coupled receptors, and LPA 4–8 is related to the purinergic family G-protein …
Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis
DL Baker, Y Fujiwara, KR Pigg, R Tsukahara… - Journal of Biological …, 2006 - ASBMB
Autotaxin (ATX, nucleotide pyrophosphate/phosphodiesterase-2) is an autocrine motility
factor initially characterized from A2058 melanoma cell-conditioned medium. ATX is known …
factor initially characterized from A2058 melanoma cell-conditioned medium. ATX is known …
Roles of specific lipid species in the cell and their molecular mechanism
Thousands of different molecular species of lipids are present within a single cell, being
involved in modulating the basic processes of life. The vast number of different lipid species …
involved in modulating the basic processes of life. The vast number of different lipid species …