Multicomponent reactions (MCRs) receive increasing attention because they address both
diversity and complexity in organic synthesis. Thus, in principle diverse sets of relatively …

A domino reaction has been defined by Tietze as a reaction involving two or more bond-
forming transformations that take place under the same reaction conditions, without adding …

In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has
received much attention. This because they have shown in many cases enhanced …

The shortcomings of native peptides as pharmaceuticals have been long known: short
duration of action, lack of receptor selectivity, lack of oral bioavailability. However medicinal …

Rongalite, also called Rongalit (Rongal-registered trademark of BASF), is sodium
hydroxymethanesulfinate dihydrate, which is represented by the chemical formula …

Here we describe several useful strategies to a variety of unusual α-amino acid derivatives
and peptides based on “building block” approach. These building blocks are suitable for …

The outstanding physio-pathological role played by integrin receptors in living subjects
motivates the enormous interest shown by scientists worldwide for this topic. More than …

Medicinal chemistry has witnessed major advances with the discovery of small synthetic
molecules that mimic natural peptidic substrates. These small synthetic mimics do not …

The term “conformational restriction” can be found very often in contemporary chemical
literature. Despite the lack of strict definitions, this term is usually intuitively understood and …

α-Amino acids are one type of the main building blocks of living systems, being the primary
components of all naturally occurring peptides and proteins. They are the simplest optically …