Cancer genome-sequencing studies have revealed a remarkably high prevalence of
mutations in genes encoding subunits of the SWI/SNF chromatin-remodelling complexes …

Small molecule-based targeting of chromatin regulatory factors has emerged as a promising
therapeutic strategy in recent years. The development and ongoing clinical evaluation of …

The genetic concept of synthetic lethality has now been validated clinically through the
demonstrated efficacy of poly (ADP-ribose) polymerase (PARP) inhibitors for the treatment of …

Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, is a leading
cause of cancer-related death worldwide. It is highly refractory to most systemic therapies …

Mutations in ARID1A rank among the most common molecular aberrations in human cancer.
However, oncogenic consequences of ARID1A mutation in human cells remain poorly …

In the past few years, it has become clear that mutations in epigenetic regulatory genes are
common in human cancers. Therapeutic strategies are now being developed to target …

Background Several cancer types harbor alterations in the gene encoding AT-Rich
Interactive Domain-containing protein 1A (ARID1A), but there are no approved therapies to …

Innovative molecular diagnostics deployed in the clinic enable new ways to stratify patients
into appropriate treatment regimens. These approaches may resolve a major challenge for …

Multi-subunit ATPase-dependent chromatin remodelling complexes SWI/SNF
(switch/sucrose non-fermentable) are fundamental epigenetic regulators of gene …

Ovarian clear cell (OCCC) and endometrioid (EnOC) carcinomas are often subsumed under
the umbrella term “endometriosis-associated ovarian cancer”(EAOC), since they frequently …