For immobile plants, the main means of protection against adverse environmental factors is
the biosynthesis of various secondary (specialized) metabolites. The extreme diversity and …

Transmission represents a population bottleneck in the Plasmodium life cycle and a key
intervention target of ongoing efforts to eradicate malaria. Sexual differentiation is essential …

Malaria is a devastating disease caused by the protozoan parasite Plasmodium. The most
common Plasmodium species that infect humans are Plasmodium falciparum and …

The apicomplexan parasite Cryptosporidium is a leading global cause of severe diarrhoeal
disease and an important contributor to early childhood mortality. Currently, there are no …

The primary antigenic and virulence determinant of the human malaria parasite Plasmodium
falciparum is a variant surface protein called PfEMP1. Different forms of PfEMP1 are …

High-throughput phenotypic screening of chemical libraries has resulted in the identification
of thousands of compounds with potent antimalarial activity, although in most cases, the …

The human malaria parasite Plasmodium falciparum harbors a relict, nonphotosynthetic
plastid of algal origin termed the apicoplast. Although considerable progress has been …

Better understanding of the molecular changes associated with disease is essential for
identifying new routes to improved therapeutics and diagnostic tests. The aim of this study …

Malaria is a global infectious disease that threatens the lives of millions of people.
Transcriptomics, proteomics and functional genomics studies, as well as sequencing of the …

Metabolomics-based studies are proving of great utility in the analysis of modes of action
(MOAs) and resistance mechanisms of drugs in parasitic protozoa. They have helped to …