Transplantation, the gold standard intervention for organ failure, is a clinical field that is ripe
for applications of gene therapy. One of the major challenges in applying gene therapy to …

Background Reliable biomarkers for assessing the viability of the donor hearts undergoing
ex vivo perfusion remain elusive. A unique feature of normothermic ex vivo perfusion on the …

Preclinical disease models are important for the advancement of therapeutics towards
human clinical trials. One of the difficult tasks of developing a well-characterized model is …

Recent advances in ex vivo perfusion have enabled an extended preservation time for solid
organs prior to transplantation allowing for possible resuscitation of the donor organ during …

Gene therapy is an advanced treatment approach that alters the genetic composition of cells
to confer therapeutic protein or RNA expression to the target organ. It has been successfully …

Background Second warm ischemia (SWI) injury between the completion of vascular
anastomosis and graft reperfusion has been a longstanding issue in organ transplantation …

The porcine intra-abdominal heterotopic heart transplantation model allows for the
assessment of immunologic effects on cardiac transplantation without relying on the allograft …