Immunological face of megakaryocytes

Y Li, K Chen, QF Wang - Frontiers of Medicine, 2024 - Springer
Megakaryocytes (MKs), which are traditionally known for their role in platelet production, are
now emerging as unique immune cells with diverse capabilities. They express immune …

Research progress of megakaryocytes and platelets in lung injury

T Hua, G Zhang, Y Yao, H Jia, W Liu - Annals of Medicine, 2024 - Taylor & Francis
The lung is an important site of extramedullary platelet formation, and megakaryocytes in the
lung participate in immune responses in addition to platelet production. In acute lung injury …

Harmine promotes megakaryocyte differentiation and thrombopoiesis by activating the Rac1/Cdc42/JNK pathway through a potential target of 5‐HTR2A

X Liu, J Lai, X Zhang, A Wu, L Zhou, Y Li… - Phytotherapy …, 2024 - Wiley Online Library
Abstract Harmine (HM), a β‐carboline alkaloid extracted from plants, is a crucial component
of traditional Chinese medicine (TCM) known for its diverse pharmacological activities …

The lung is a megakaryocyte outpost that can defend against thrombocytopenic attack

AK Yeung, GJ Murphy - The Journal of Clinical Investigation, 2024 - jci.org
Lung megakaryocytes (Mks) are a unique subset of Mks that are distinct from their bone
marrow counterparts. Recent evidence suggests that lung Mks favor an immune phenotype …

AC-73 and Syrosingopine Inhibit SARS-CoV-2 Entry into Megakaryocytes by Targeting CD147 and MCT4

I Spinello, E Saulle, MT Quaranta, E Pelosi, G Castelli… - Viruses, 2024 - mdpi.com
Coagulation disorders are described in COVID-19 and long COVID patients. In particular,
SARS-CoV-2 infection in megakaryocytes, which are precursors of platelets involved in …

HMGA2 promotes platelet-neutrophil complex formation and pulmonary tissue damage in myelodysplastic syndromes

N Matsunuma, Y Hayashi, M Fukuda… - Blood Vessels …, 2024 - ashpublications.org
High mobility group AT-hook 2 (HMGA2) is an architectural transcription factor that functions
as an oncogene in various cancers. Although overexpression of HMGA2 has been reported …

Time-Dependent Changes in Pulmonary Turnover of Thrombocytes During Critical COVID-19

NR Aarskog, R Hallem, JS Godhavn… - Critical Care …, 2024 - journals.lww.com
DESIGN: Cohort study with repeated measurements of arterial and central venous
thrombocyte counts. SETTING: ICU in a large university hospital. PATIENTS: Thirty-one …

[PDF][PDF] Factors Involved in Megakaryocytosis and Platelet Origin

SS Hassan, EF Alkhalidi… - Journal of Natural Science …, 2024 - researchgate.net
Background: Developments in the field of platelet biology led to attention given to their
origins and constituents. Objectives: we aimed to highlight the important factors involved in …

[HTML][HTML] Altered platelet quality and dynamics in patients undergoing hemodialysis

K Tateno, K Sugimura, Y Fujimoto, A Kawamura - Vessel Plus, 2024 - oaepublish.com
Patients undergoing hemodialysis (HD) are at high risk for both atherothrombosis and
hemorrhage. Compared to healthy individuals, these patients show significant alterations in …

[HTML][HTML] Роль тромбоцитов в патогенезе инфекционно-воспалительных заболеваний легких у детей (обзор литературы)

ЕМ Толстова, МВ Беседина, ОВ Зайцева… - РМЖ. Мать и …, 2024 - cyberleninka.ru
Взаимодействие систем иммунитета и гемостаза в настоящее время является
предметом научного интереса. В последнее десятилетие получены новые данные об …