CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

Proteins of the CLC gene family assemble to homo-or sometimes heterodimers and either
function as Cl–channels or as Cl–/H+-exchangers. CLC proteins are present in all phyla …

Ion channels are key regulators of cancer cell pathophysiology. They contribute to a variety
of processes such as maintenance of cellular osmolarity and membrane potential, motility …

ClC-2 transports chloride ions across plasma membranes and plays critical roles in cellular
homeostasis. Its dysfunction is involved in diseases including leukodystrophy and primary …

Antibiotic resistance (AR) is an acute problem that results in prolonged and debilitating
illnesses. AR mortality worldwide is growing and causes a pressing need to research novel …

Group A Streptococcus (GAS, Streptococcus pyogenes) is a Gram-positive human pathogen
that employs several secreted and surface-bound virulence factors to manipulate its …

Myotonia congenita (MC) is caused by loss-of-function mutations of the muscle ClC-1
chloride channel. Clinical manifestations include the variable association of myotonia and …

Cl− channels activated by acidic extracellular pH have been observed in various
mammalian cells but their molecular identity and mechanisms of regulation are unknown …

The ClC protein family includes voltage-gated chloride channels and chloride/proton
exchangers. In eukaryotes, ClC proteins regulate membrane potential of excitable cells …

Apoptosis is an important mechanism of cell demise in multicellular organisms and Cl−
transport has an important role in the progression of the apoptotic volume decrease (AVD) …