The Blood–Brain Barrier: Composition, Properties, and Roles in Brain Health
Blood vessels are critical to deliver oxygen and nutrients to tissues and organs throughout
the body. The blood vessels that vascularize the central nervous system (CNS) possess …
the body. The blood vessels that vascularize the central nervous system (CNS) possess …
Nutrition and mental health: A review of current knowledge about the impact of diet on mental health
M Grajek, K Krupa-Kotara, A Białek-Dratwa… - Frontiers in …, 2022 - frontiersin.org
Applied psychopharmacotherapy and psychotherapy do not always bring the expected
results in the treatment of mental disorders. As a result, other interventions are receiving …
results in the treatment of mental disorders. As a result, other interventions are receiving …
Improved AlphaFold modeling with implicit experimental information
Abstract Machine-learning prediction algorithms such as AlphaFold and RoseTTAFold can
create remarkably accurate protein models, but these models usually have some regions …
create remarkably accurate protein models, but these models usually have some regions …
Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold
R Castells-Graells, K Meador… - Proceedings of the …, 2023 - National Acad Sciences
Cryoelectron microscopy (Cryo-EM) has enabled structural determination of proteins larger
than about 50 kDa, including many intractable by any other method, but it has largely failed …
than about 50 kDa, including many intractable by any other method, but it has largely failed …
Spns1 is a lysophospholipid transporter mediating lysosomal phospholipid salvage
The lysosome is central to the degradation of proteins, carbohydrates, and lipids and their
salvage back to the cytosol for reutilization. Lysosomal transporters for amino acids, sugars …
salvage back to the cytosol for reutilization. Lysosomal transporters for amino acids, sugars …
Structure of human drug transporters OATP1B1 and OATP1B3
The organic anion transporting polypeptides OATP1B1 and OATP1B3 are membrane
proteins that mediate uptake of drugs into the liver for subsequent conjugation and biliary …
proteins that mediate uptake of drugs into the liver for subsequent conjugation and biliary …
Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins
With conformation-specific nanobodies being used for a wide range of structural,
biochemical, and cell biological applications, there is a demand for antigen-binding …
biochemical, and cell biological applications, there is a demand for antigen-binding …
Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate
Summary Sphingosine-1-phosphate (S1P) is an important signaling sphingolipid that
regulates the immune system, angiogenesis, auditory function, and epithelial and …
regulates the immune system, angiogenesis, auditory function, and epithelial and …
The role of SLC transporters for brain health and disease
YTK Nguyen, HTT Ha, TH Nguyen… - Cellular and Molecular Life …, 2022 - Springer
The brain exchanges nutrients and small molecules with blood via the blood–brain barrier
(BBB). Approximately 20% energy intake for the body is consumed by the brain. Glucose is …
(BBB). Approximately 20% energy intake for the body is consumed by the brain. Glucose is …
Mfsd2a utilizes a flippase mechanism to mediate omega-3 fatty acid lysolipid transport
Major Facilitator Superfamily Domain containing 2a (Mfsd2a) is a sodium-dependent
lysophosphatidylcholine (LPC) transporter expressed at the blood–brain barrier that …
lysophosphatidylcholine (LPC) transporter expressed at the blood–brain barrier that …