Doxorubicin-induced cardiotoxicity: an overview on pre-clinical therapeutic approaches
Doxorubicin is an effective chemotherapeutic agent prescribed to treat solid tumors (eg,
ovary, breast, and gastrointestinal cancers). This anti-cancer drug has various side effects …
ovary, breast, and gastrointestinal cancers). This anti-cancer drug has various side effects …
A comprehensive insight into the anti-inflammatory properties of dapsone
M Khalilzadeh, M Shayan, S Jourian, M Rahimi… - Naunyn-Schmiedeberg's …, 2022 - Springer
Abstract The 4, 4′-diaminodiphenyl sulfone (DDS), also known as dapsone, is traditionally
used as a potent anti-bacterial agent in clinical management of leprosy. For decades …
used as a potent anti-bacterial agent in clinical management of leprosy. For decades …
Ellagic acid reduces methotrexate-induced apoptosis and mitochondrial dysfunction via up-regulating Nrf2 expression and inhibiting the IĸBα/NFĸB in rats
R Ebrahimi, MR Sepand, SA Seyednejad… - DARU Journal of …, 2019 - Springer
Background The clinical application of methotrexate (MTX), an efficacious cytotoxic drug, is
restricted due to its associated liver toxicity. Ellagic acid (EA), a natural polyphenol …
restricted due to its associated liver toxicity. Ellagic acid (EA), a natural polyphenol …
Beyond its anti‐migraine properties, sumatriptan is an anti‐inflammatory agent: A systematic review
Sumatriptan is the first available medication from triptans family that was approved by the US
Food and Drug Administration for migraine attacks and cluster headaches in 1991. Most of …
Food and Drug Administration for migraine attacks and cluster headaches in 1991. Most of …
Cigarette smoke-induced toxicity consequences of intracellular iron dysregulation and ferroptosis
Despite numerous studies on the mechanisms of cigarette smoking toxicity over the past
three decades, some aspects remain obscure. Recent developments have drawn attention …
three decades, some aspects remain obscure. Recent developments have drawn attention …
Sumatriptan alleviates radiation-induced oral mucositis in rats by inhibition of NF-kB and ERK activation, prevention of TNF-α and ROS release
Objectives Oral mucositis caused by radiation therapy is a common problem in cancer
patients, especially those with head and neck cancer. Numerous experimental and clinical …
patients, especially those with head and neck cancer. Numerous experimental and clinical …
Duality in response of intracranial vessels to nitroglycerin revealed in rats by imaging photoplethysmography
AY Sokolov, MA Volynsky, AV Potapenko… - Scientific Reports, 2023 - nature.com
Among numerous approaches to the study of migraine, the nitroglycerin (NTG) model
occupies a prominent place, but there is relatively insufficient information about how NTG …
occupies a prominent place, but there is relatively insufficient information about how NTG …
5-HT/CGRP pathway and Sumatriptan role in Covid-19
ABSTRACT Coronavirus disease 2019 (Covid-19) is a pandemic caused by severe acute
respiratory syndrome coronavirus type 2 (SARS-CoV-2). In Covid-19, there is uncontrolled …
respiratory syndrome coronavirus type 2 (SARS-CoV-2). In Covid-19, there is uncontrolled …
Effect of sumatriptan on acetic acid-induced experimental colitis in rats: a possible role for the 5‐HT1B/1D receptors
R Hosseini, N Fakhraei, H Malekisarvar… - Naunyn-Schmiedeberg's …, 2022 - Springer
Mucosal inflammation in colitis is associated with changes in the intestinal serotonin (5-HT)
level. Sumatriptan, a 5‐HT1B/1D receptor agonist, has demonstrated anti-inflammatory …
level. Sumatriptan, a 5‐HT1B/1D receptor agonist, has demonstrated anti-inflammatory …
[PDF][PDF] Anti-inflammatory and antioxidative effects of sumatriptan against doxorubicin-induced cardiotoxicity in rat
The clinical use of doxorubicin as a potent chemotherapeutic agent is limited due to its
dosedependent cardiotoxicity. Oxidative stress and inflammatory pathways have a pivotal …
dosedependent cardiotoxicity. Oxidative stress and inflammatory pathways have a pivotal …