Changes in cell surface glycosylation are a hallmark of the transition from normal to inflamed
and neoplastic tissue. Tumor-associated carbohydrate antigens (TACAs) challenge our …

A basic tenet of antibody-based immunity is their specificity to antigenic determinates from
foreign pathogen products to abnormal cellular components such as in cancer. However, an …

Tumor-associated carbohydrate antigens (TACAs) support cell survival that could be
interrupted by anti-TACA antibodies. Among TACAs that mediate cell survival signals are the …

Introduction Because of its restricted distribution in normal tissues and its high expression on
tumors of neuroectodermal origin, GD2 ganglioside is an excellent target for active specific …

To understand the mechanisms underlying bone marrow metastasis precisely, we
established the highly metastatic 4T1E/M3 murine breast cancer cell line. 4T1 murine breast …

Molecular mimicry is fundamental to biology and transcends to many disciplines ranging
from immune pathology to drug design. Structural characterization of molecular partners has …

Background The number of breast cancer patients diagnosed with ductal carcinoma in situ
(DCIS) continues to grow. Laboratory and clinical data indicate that DCIS can progress to …

Tumor-Associated Carbohydrate Antigens (TACAs) are broad-spectrum targets for
immunotherapy. Immunization with Carbohydrate Mimetic Peptides (CMPs) is a strategy to …

The immune system plays an intricate role in tumorigenesis, therefore cancer
immunotherapy borrows concepts both from autoimmunity and vaccinology. Due to tumor …

Limited immune responses to tumor-associated carbohydrate antigens (TACA) are due in
part to their being self-antigens. Immunization with xenoantigens of TACA provides an …